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投稿时间：2023-09-22 网络发布日期：2024-05-20
投稿时间：2023-09-22 网络发布日期：2024-05-20
中文摘要: 乳腺癌发病率位居女性恶性肿瘤发病率之首。近年来越来越多的研究表明肠道微生态与乳腺癌的发生密切相关。中医理论中“从脾论治”涉及“脾主运化、脾主升清、脾藏意主思、脾为之卫”诸多方面，肠道菌群与上述生理职能具有颇高相似性。故本文基于肠道菌群探讨从脾论治乳腺癌的科学内涵，为中医学从脾论治乳腺癌提供分子机制层面的依据，以期拓宽乳腺癌的中西医诊疗思路。
Abstract:Breast cancer is a global problem that jeopardizes women's health, and its incidence ranks the first female malignant tumors. Recently, more and more studies have shown a significant association between intestinal microecology and the development of breast cancer. In Chinese medicine theory, “treating from the spleen” involves “the spleen is the master of transportation, the spleen is the master of ascending and clearing, the spleen is the master of thinking, and the spleen is the guardian”, and the intestinal microecology has a high similarity with the above physiological functions. Therefore, based on the intestinal flora, this article would discuss the scientific connotation of treating breast cancer with the spleen theory, and provide the molecular mechanism of breast cancer treatment with the spleen theory for Chinese medicine, with the aim of broadening the ideas of Chinese and Western medical diagnosis and treatment of breast cancer.
keywords: Intestinal flora Breast cancer Treatment from spleen Estrogen Epigenetic inheritance Microbiota
文章编号： 中图分类号：R259 R737.9 文献标志码：A
基金项目:黑龙江省自然科学基金面上项目（H2018054）；黑龙江省级名中医专家传承工作室建设项目（〔2020〕55号）；黑龙江省卫生健康委科研课题（20220404010995）；黑龙江省中医药科研项目（ZHY2022-002）
附件
| 作者 | 单位 |
| 孙心悦 | 1. 黑龙江中医药大学，黑龙江 哈尔滨 150040；2. 哈尔滨市中医医院，黑龙江 哈尔滨 150076 |
| 葛梦迪 | 1. 黑龙江中医药大学，黑龙江 哈尔滨 150040 |
| 王宽宇 | 1. 黑龙江中医药大学，黑龙江 哈尔滨 150040；3. 黑龙江中医药大学附属第一医院外二科，黑龙江 哈尔滨 150040 |
| 贺紫薇 | 1. 黑龙江中医药大学，黑龙江 哈尔滨 150040 |
| Author Name | Affiliation |
| SUN Xinyue*, GE Mengdi, WANG Kuanyu, HE Ziwei | *Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China |
引用文本：
孙心悦,葛梦迪,王宽宇,等.基于肠道菌群探讨乳腺癌从脾论治的作用机制[J].中国临床研究,2024,37(5):788-792.
孙心悦,葛梦迪,王宽宇,等.基于肠道菌群探讨乳腺癌从脾论治的作用机制[J].中国临床研究,2024,37(5):788-792.