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投稿时间:2023-10-12 网络发布日期:2023-12-20
投稿时间:2023-10-12 网络发布日期:2023-12-20
中文摘要: 目的 探讨妊娠期糖尿病(GDM)患者阴道微生态、糖脂代谢水平,及其与妊娠结局的相关性。方法 选取2019年1月至2022年10月在宁德市医院就诊的150例GDM患者为观察组,另选取70例同期体检健康的正常妊娠孕妇为对照组。检测所有孕妇的阴道微生态、糖脂代谢水平。 Logistic回归分析GDM患者妊娠结局不良的影响因素。结果 观察组患者阴道微生态失衡率高于对照组[59.33%(89/150)vs 21.43%(15/70), χ2=27.511,P<0.01)]。观察组三酰甘油(TG)、总胆固醇(TC)、空腹血糖、低密度脂蛋白胆固醇(LDL-C)、胰岛素、糖化血红蛋白(HbA1c)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平高于对照组,白蛋白水平低于对照组(P<0.05);两组阴道pH值比较差异有统计学意义(P<0.05)。观察组不良妊娠结局总发生率高于对照组,差异有统计学意义(34.67% vs 7.14%, χ2=18.835,P<0.01)。Logistic回归分析显示,阴道微生态失衡及高水平的TC、空腹血糖、胰岛素、HbA1c、IL-6为GDM患者妊娠结局不良的独立影响因素(P<0.01)。结论 GDM可导致孕妇糖脂代谢水平异常、阴道微生态失衡,进而可能影响妊娠结局。
Abstract:Objective To investigate vaginal microecology, glycolipid metabolism levels in patients with gestational diabetes mellitus (GDM), and their correlation with pregnancy outcome.
Methods A total of 150 GDM patients who received treatment at Ningde Municipal Hospital from January 2019 to October 2022 were selected as observation group, and other 70 healthy women with normal pregnancy were selected as the control group. The levels of vaginal microecology, glycolipid metabolism were detected. Logistic regression was used to analyze the adverse factors affecting pregnancy outcomes in GDM patients.
Results The imbalance rate of vaginal microbiota in the observation group was higher than that in the control group [59.33%(89/150)vs 21.43%(15/70), χ2=27.51, P<0.01]. Compared with control group, observation group had higher levels of triglycerides (TG), total cholesterol (TC), fasting blood glucose, low-density lipoprotein cholesterol (LDL-C), insulin, glycosylated hemoglobin (HbA1c), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP), and had lower level of albumin (P<0.05). There was a significant difference in vaginal pH between the two groups (P<0.05). The total incidence of adverse pregnancy outcomes in the observation group was higher than that in the control group (34.67% vs 7.14%, χ2=18.835, P<0.01). Logistic regression analysis showed that vaginal microbiota imbalance, as well as high level of TC, fasting blood glucose, insulin, HbA1c and IL-6 were the independent influencing factors for poor pregnancy outcomes in GDM patients.
Conclusion GDM can lead to abnormal glycolipid metabolism levels in pregnant women, as well as imbalance in vaginal microbiota, which may affect pregnancy outcomes.
keywords: Gestational diabetes mellitus Vaginal microecology Glycolipid metabolism Pregnancy outcome Glycosylated hemoglobin Interleukin
文章编号: 中图分类号:R714.256 文献标志码:A
基金项目:
Author Name | Affiliation |
WU Qinjuan, LEI Xiaolin, HUANG Xiaochun, CHEN Xunyan | Obstetrical Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian 352100, China |
引用文本:
吴勤娟,雷晓琳,黄小春,陈洵艳.妊娠期糖尿病患者阴道微生态和糖脂代谢水平与妊娠结局的相关性[J].中国临床研究,2023,36(12):1807-1810,1815.
吴勤娟,雷晓琳,黄小春,陈洵艳.妊娠期糖尿病患者阴道微生态和糖脂代谢水平与妊娠结局的相关性[J].中国临床研究,2023,36(12):1807-1810,1815.