Abstract:Objective To study the value of lumbar cistern drainage combined with intrathecal injection in the treatment of pan-drug resistant Acinetobacter baumannii intracranial infection after craniotomy in prefecture level hospitals. Methods A retrospective study was conducted on the treatment of 60 patients with pan-drug resistant Acinetobacter baumannii intracranial infection after craniotomy at Ezhou Central Hospital from 2018 to 2022. Intravenous antibiotics were given for 8 weeks immediately after the infection was confirmed in study group (n=30) and control group (n=30), and the study group received lumbar cistern drainage plus intrathecal injection at the same time, while the control group underwent intrathecal injection at the same time, and the latter treatment courses of the two groups was determined according to the review of cerebrospinal fluid.The total effective rates in the two groups were evaluated after 8 weeks of antibiotic treatment, and the time of recovery of body temperature, remission of meningeal irritation, remission of elevated intracranial pressure and adverse reactions were counted. The blood levels of C-reactive protein (CRP), procalcitonin (PCT), neuron-specific enolase (NSE) , while cerebrospinal fluid (CSF) levels of white blood cell count (WBC), neutrophil percentage (NEUT), protein and glucose were compared before and after treatment between two groups. Results The total effective rate of the study group was 86.67%, higher than 63.33% of the control group(χ²=4.365, P<0.05). The time for temperature recovery, relief of meningeal irritation sign, and relief of intracranial pressure increase in the study group were all shorter than those in the control group(P<0.01). After 8 weeks of antibiotic treatment, the blood levels of CRP, PCT, and NSE of the study group were lower than those of the control group(P<0.05)and the CSF levels of NEUT, protein and WBC were lower than those of the control group, but glucose was higher than that of the control group(P<0.05). The adverse reaction in the study group were 10.00%, lower than that in the control group(33.33%, P<0.05). Conclusion For patients with intracranial infection caused by pan-drug resistant Acinetobacter baumannii after craniotomy, the effect of lumbar cistern drainage combined with intrathecal injection is more ideal, which can promote symptom relief, quickly control infection, improve CSF environment, reduce adverse reactions, and have high safety. It can be promoted and used in prefecture level hospitals.