Abstract:With the deepening of aging society, the incidence of perioperative neurocognitive disorders（PND） has also increased, resulting in lower quality of life of patients and increased medical burden. Therefore, it is of great significance to study the mechanism and prevention measures of PND. Accumulating evidence has shown that gut microbiota is closely related to the occurrence of a variety of central nervous system diseases that alter cognitive function and can participate in the occurrence and development of PND through its metabolites and other multiple ways. This paper analyzes and summarizes the relevant literature in recent years to explore the relationship between gut microbiota metabolites and perioperative neurocognitive disorders, so as to provide some guidance for clinical practice.