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投稿时间：2022-11-16 网络发布日期：2022-12-20
投稿时间：2022-11-16 网络发布日期：2022-12-20
中文摘要: 目的 分析多成分非药物性干预对糖皮质激素治疗非特异性间质性肺炎（NSIP）的作用及对抑郁情绪、生活质量的影响。 方法 选取2021年4月至12月南京大学医学院附属鼓楼医院治疗的NSIP患者120例，采用随机数字表法分为试验组和对照组，各60例。对照组采用糖皮质激素治疗，试验组在对照组基础上采用多成分非药物性干预。记录患者抑郁情绪、生活质量变化。 结果 试验组总有效率高于对照组，差异有统计学意义（93.33% vs 78.33%,P＜0.05）。试验组患者咳嗽消失、退热、肺部湿啰音消失时间短于对照组，差异有统计学意义（P＜0.01）。干预后，试验组抑郁自评量表评分低于对照组，生活质量评分高于对照组，差异有统计学意义（P＜0.01）。 结论 多成分非药物干预应用于糖皮质激素治疗NSIP中，能够有效改善患者的临床症状和抑郁情绪，提高患者的肺功能，改善生活质量。
中文关键词: 非特异性间质性肺炎；糖皮质激素；多成分非药物性干预；生活质量 抑郁
Abstract:Objective To analyze the effect of multimodal nonpharmacological interventions on glucocorticoid in the treatment of nonspecific interstitial pneumonia(NSIP), depression and quality of life. Methods One hundred and twenty patients with NSIP treated in Nanjing Drum Tower Hospital from April 2021 to December 2021 were selected, and randomly divided into test group and control group with 60 patients in each group. The control group was treated with glucocorticoid, and the test group was treated with multimodal nonpharmacological interventions on the basis of the control group. The changes of depression,quality of life were compared between the two groups. Results The total effective rate, quality of life scores of the test group were higher than those of the control group ,with a statistically significant difference (93.33% vs 78.33%, P＜0.05). The disappearance time of cough, fever and lung moist rale in the test group was shorter than that in the control group (P＜0.05). After intervention, the self depression scale score of the test group was lower than that of the control group, and the quality of life score was higher than that of the control group, with statistically significant differences (P＜0.01). Conclusion Multimodal nonpharmacological interventions applied to glucocorticoid in the treatment of NSIP can effectively ameliorate the clinical symptoms and depression, effectively strengthen the pulmonary function and improve the quality of life of patients.
keywords: Nonspecific interstitial pneumonia Glucocorticoid Multimodal nonpharmacological interventions Quality of life Depression
文章编号： 中图分类号： 文献标志码：B
基金项目:南京鼓楼医院护理科研重点项目（ZSA415-1)
附件
| 作者 | 单位 |
| 魏田田1 | 1. 南京大学医学院附属鼓楼医院呼吸与危重症医学科，江苏 南京 210000 |
| 张丽缇2 | 2. 南京中医药大学翰林学院，江苏 南京 210000 |
| 苗桂玲1 | 1. 南京大学医学院附属鼓楼医院呼吸与危重症医学科，江苏 南京 210000 |
引用文本：
魏田田,张丽缇,苗桂玲.多成分非药物性干预对非特异性间质性肺炎患者生活质量的影响[J].中国临床研究,2022,35(12):1771-1774.
魏田田,张丽缇,苗桂玲.多成分非药物性干预对非特异性间质性肺炎患者生活质量的影响[J].中国临床研究,2022,35(12):1771-1774.