Abstract:Objective To evaluate the application effect of collection and management of urine biochemical specimen based on ASK(attitude, skills and knowledge) model in patients with urolithiasis. Methods With an objective method for sampling, the patients whose urine samples were collected from June 2020 to July 2020 at a Nangjing tertiary A-level hospital were served as control group, and the patients whose urine samples collected from October 2020 to March 2021 at same hospital were selected as test group(treated with ASK model). The related self-efficacy, the qualified rate of specimens and knowledge scores were compared between two groups. Results In test group, the qualified rate of specimens(83.33% vs 0) and the score of 24-hour urine biochemical knowledge(9.03±0.56 vs 4.94±1.32) were significantly higher than those in control group(P＜0.01). The self-efficacy scores of standard collections(4.67±0.48 vs 3.69±0.90) and adherence to follow-up(3.63±0.62 vs 2.75±0.88) were significantly higher than those in control group(P＜0.01). Conclusion For the patients with urolithiasis, the quality improvement based on ASK model can improve the cognitive ability of urine biochemical specimen and the accuracy of sample collection process and enhance the awareness of preventing stone recurrence.