Abstract:Objective To explore the risk factors of peripherally inserted central catheter (PICC)-related infection in patients with breast cancer after surgery. Methods A total of 106 breast cancer patients with PICC after surgery in the First Affiliated Hospital of Bengbu Medical College from July 2020 to December 2021 were selected and divided into infection group and non-infection group according to the patients with PICC catheter-related infection or not. After comparing the postoperative conditions between two groups and analyzing the influencing factors of postoperative PICC catheter-related infection, logistic regression analysis was used to evaluate comprehensive effect of various kinds of factors on postoperative PICC catheter-related infection. Results In 12 cases (11.32%) of PICC catheter-related infection, 21 strains of pathogenic bacteria were isolated, in which gram-negative bacteria accounted for 57.14%, gram-positive bacteria accounted for 38.10%, and fungi accounted for 4.76%. Multivariate logistic regression analysis showed that age, catheter distortion, catheter blockage, long dressing change interval (equal or more than 7 days), chemotherapeutic drug extravasation, more than one times for puncture, long time for PICC placement (more than 6 months), high leukocyte count, low albumin level and diabetes mellitus were the risk factors for PICC catheter-related infection(P<0.05). Conclusion In the patients with breast cancer after operation, the incidence of PICC catheter-related infection is relatively high. Failure modes and effects analysis (FMEA) model can be used to strengthen the safety management system of catheter and to establish appropriate time for dressing replacement, based on strict implementation of aseptic technique.