Abstract:Objective To investigate the clinical value of nursing based on Roy's adaptive model for breast cancer patients during postoperative radiotherapy. Methods A total of 67 breast cancer patients receiving postoperative radiotherapy in the First People's Hospital of Chuzhou from January 2017 to December 2021 were selected and randomly divided into observation group(with Roy's adaptive model nursing, n=31) and control group (with routine nursing care, n=36). The mental health, quality of life and self-care ability were observed on admission and discharge and compared berween two groups. Results In terms of mental health at discharge, the obsessive-compulsive symptoms, anxiety and sleep and eating disorder (four aspects) were significantly improved in control group, while somatization, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, phobia and sleep and eating disorder (seven aspects) were significantly improved in observation group （P＜0.05，P＜0.01）.In terms of quality of life, the physiological and functional status were significantly improved in control group, while the physiological status, social/family status, functional status and additional concerns were obviously improved in observation group(P＜0.05，P＜0.01). In control group,the patients got improved in self-care skills and health knowledge, while the patients got significantly improved in self-concept, self-responsibility, self-care skills and health knowledge in observation group(P＜0.05，P＜0.01). Conclusion During postoperative radiotherapy for breast cancer, nursing intervention based on Roy's adaption model can significantly improve the patients' mental health, quality of life and self-care ability from multiple dimensions.