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投稿时间：2022-05-31 网络发布日期：2022-09-20
投稿时间：2022-05-31 网络发布日期：2022-09-20
中文摘要: Toll 样受体9（TLR9）是一种模式识别受体，可以参与识别病原相关分子模式（PAMPs），是近年肿瘤学及免疫学专家关注的重要对象之一。研究结果表明，TLR9在许多恶性肿瘤细胞中表达异常，其信号转导通路的激活在促进炎症反应、凋亡和肿瘤形成过程中起举足轻重的作用。它还可通过促进肿瘤微环境形成，参与肿瘤细胞的增殖、迁移、侵袭及免疫逃逸等。现就TLR9与卵巢恶性肿瘤、宫颈恶性肿瘤及子宫内膜恶性肿瘤的研究进展作一综述。
Abstract:Toll-like receptor 9 (TLR9) is a pattern recognition receptor, which can participate in the recognition of pathogen related molecular patterns (PAMPs). It is one of the important objects concerned by oncology and Immunology experts in recent years. The results show that TLR9 is abnormally expressed in many malignant tumor cells, and the activation of its signal transduction pathway plays an important role in promoting inflammatory response, apoptosis and tumor formation. It can also participate in the proliferation, migration, invasion and immune escape of tumor cells by promoting the formation of tumor microenvironment. This paper reviews the research progress of TLR9 and ovarian malignancies, cervical malignancies and endometrial malignancies.
keywords: Toll like receptor 9 Malignant tumor Ovarian malignant tumor Cervical carcinoma Endometrial carcinoma Inflammatory response Tumor microenvironment Immune escape
文章编号： 中图分类号：R737.3 文献标志码：A
基金项目:山西省重点研发计划项目（201803D31111）
附件
| Author Name | Affiliation |
| WANG Li-li* | *Graduate School of Shanxi Medical University, Taiyuan, Shanxi 030001, China |
| ZHANG San-yuan |
引用文本：
王丽丽,张三元.Toll样受体9在妇科恶性肿瘤中的研究进展[J].中国临床研究,2022,35(9):1249-1252.
王丽丽,张三元.Toll样受体9在妇科恶性肿瘤中的研究进展[J].中国临床研究,2022,35(9):1249-1252.