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网络发布日期：2022-08-20
网络发布日期：2022-08-20
中文摘要: 目的 探讨血清IL-34与活动性肺结核严重程度的相关性，并分析其对疗效的预测价值。方法 选择2018年6月至2020年1月在三峡医院接受治疗的活动性肺结核患者103例为观察组，选择同期住院的社区获得性肺炎患者103例作为对照组。以双抗体夹心ELISA法检测IL-34、C-反应蛋白（CRP）水平。观察组患者均给予2HRZE/4HR化疗方案治疗，治疗2个月后进行疗效评价并分为有效组与无效组。比较不同组间IL-34、CRP水平及IL-34、CRP对活动期肺结核患者疗效的预测价值。结果 观察组患者血清IL-34、CRP水平均高于对照组（P<0.01）；有空洞的肺结核患者IL-34、CRP水平均高于无空洞者（P<0.01）；≥3个肺野的肺结核患者IL-34与CRP水平均高于＜3个肺野者（P<0.01）。活动性肺结核患者IL-34与CRP水平与病灶范围均呈显著正相关关系（P＜0.05）。无效组患者IL-34与CRP水平均高于有效组（P<0.01）。血清IL-34、CRP对活动性肺结核患者疗效预测的截断值分别为46.29 pg/ml、27.93 mg/L；曲线下面积（AUC）分别为0.882、0.764，二者联合诊断的AUC为0.958，其诊断效能高于各指标单独检测（P＜0.05）。结论 活动性肺结核患者血清IL-34、CRP水平高于社区获得性肺炎患者，且与肺结核严重程度呈正相关，血清IL-34＞46.29 pg/ml、CRP＞27.93 mg/L时提示预后不良。
Abstract:Objective To investigate the correlation between serum IL-34 and the severity of active pulmonary tuberculosis patients, and to analyze its efficacy prediction value. Methods From June 2018 to January 2020, 103 cases of active pulmonary tuberculosis treated in Three Gorges Hospital were selected as the observation group. 103 cases of community acquired pneumonia were selected as control group. The IL-34 and C-reactive protein（CRP）levels were detected by double-antibody sandwich ELISA. All patients in the observation group were treated with 2HRZE/4HR chemotherapy regimen. The efficacy was evaluated after 2 months of treatment, they were divided into effective group and ineffective group. The levels of IL-34 and CRP were compared between different groups. The predictive value of IL-34 and CRP on the curative effect of patients with active pulmonary tuberculosis were analyzed. Results The serum levels of IL-34 and CRP in observation group were higher than those in control group (P<0.01). The levels of IL-34 and CRP in pulmonary tuberculosis patients with cavities were higher than those without cavities (P<0.01); The levels of IL-34 and CRP in tuberculosis patients with≥3 lung fields were higher than those with<3 lung fields (P<0.01). The levels of IL-34 and CRP in patients with active tuberculosis were significantly positively correlated with the extent of the lesion （P＜0.05）.The levels of IL-34 and CRP in patients with active pulmonary tuberculosis in the ineffective group were higher than those in the effective group (P<0.01). ROC analysis showed that the cut-off values of serum IL-34 and CRP for predicting the therapeutic effect of patients with active pulmonary tuberculosis were 46.29 pg/ml and 27.93 mg/L, respectively; the area under the curve (AUC) was 0.882 and 0.764 respectively. The AUC of combined diagnosis was 0.958, which was higher than that of single detection （P＜0.05）. Conclusion The serum IL-34 and CRP levels of patients with active pulmonary tuberculosis were higher than those of community acquired pneumonia groups, and their serum IL-34 and CRP levels were positively correlated with the severity. Serum IL-34 was greater than 46.29 pg/ml, CRP greater than 27.93 mg/L indicates poor prognosis.
文章编号： 中图分类号：R521 文献标志码：B
基金项目:重庆市卫计委课题 （ZY201703067）
| Author Name | Affiliation |
| LIU Lin, JIANG Qiu, TIAN Bing, ZHAO Chun-e, CHEN Rui-hua | Department of Infectious Diseases, Three Gorges Hospital Affiliated to Chongqing University, Chongqing 404000, China |
引用文本：
刘林，蒋秋，田冰，赵春娥，陈瑞华.血清IL-34与活动性肺结核严重程度的相关性及其疗效判断价值[J].中国临床研究,2022,35(8):1102-1105，1110.
刘林，蒋秋，田冰，赵春娥，陈瑞华.血清IL-34与活动性肺结核严重程度的相关性及其疗效判断价值[J].中国临床研究,2022,35(8):1102-1105，1110.