Abstract:Objective To explore the associations of serum soluble factor associated suicide (sFas) and sFas ligand (sFasL) with the severity of angina pectoris and its predictive value for cardiac function. Methods A total of 110 angina pectoris patients in accordance with the diagnosis of chronic stable angina pectoris treated in Anhui Second Provincial People's Hospital from September 2019 to July 2020 were divided into single vessel lesion group (n=34), double vessel lesion group (n=57) and three vessel lesion group (n=19),and according to the cardiac function classification of the New York Heart Association (NYHA), each group further classified into heart failure (HF) sub-group (NYHA Ⅱ-Ⅳ grade) and non-HF sub-group (NYHA Ⅰ-grade). The related clinical data and indicators were statistically analyzed in two groups, and the associations of serum sFas and sFasL with the severity of coronary artery lesion and cardiac function were explored respectively. The associations of sFas and sFasL in the patients with different degrees of coronary artery lesions of angina pectoris with cardiac function were analyzed by receiver operating curve (ROC). Results In the patients with single vessel lesion, there was no significant difference in the levels of sFas and sFasL between HF sub-group and non-HF sub-group (P>0.05). In the patients with double vessel lesion and three vessel lesion, the levels of sFas and sFasL in HF sub-group were significantly higher than those in non-HF sub-group (P<0.05, P＜0.01). Logistic regression analysis showed that sFas and sFasL were the independent risk factors for the occurrence of HF. ROC curve showed that the areas under curve(AUC) of sFas and sFasL for the prediction of HF were 0.725 and 0.620,respectively, and AUC of sFas combined with sFasL was 0.755. Conclusion Both sFas and sFasL have certain predictive value for HF in angina pectoris patients with multi-vessel coronary artery disease.