Abstract:Objective To explore the characteristics of comorbid cognitive impairment in children with epilepsy, and to provide reference basis for the treatment of comorbid cognitive impairment in children with epilepsy. Methods A retrospective study was conducted on 450 children with epilepsy aged 6 to 12 years diagnosed in Tangshan Maternal and Child Health Hospital from January 2013 to January 2017. At the same time, 50 healthy children aged 6 to 12 years were selected as controls for questionnaire survey. According to the survey Results, children with epilepsy were divided into epilepsy group and epilepsy comorbid group. The cognitive function of the investigated children was evaluated by Montreal cognitive assessment scale (MoCA), and the childrens quality of life questionnaire was conducted by Quality of Life in PilePsy-31 (QOLIE-31). According to the evaluation Results, the clinical characteristics of comorbid cognitive impairment of children with epilepsy and its impact on quality of life were analyzed. Results MoCA evaluation showed that among 450 children with epilepsy, 178 cases were in the epilepsy comorbidity group and 272 cases in the epilepsy group. MoCA score showed that there were significant differences in visual space and execution, attention, language function, abstract ability, memory, and total score among three groups （ P <0.05， P <0.01）； but there was no significant difference in the scores and total scores of MoCA among focal seizures, generalized tonic seizures and absence seizures（ P >0.05）. QOLIE-31 score Results showed that there were significant differences in social function, seizure worry, drug impact, life satisfaction, energy state, emotional state, cognitive function and total scores of 7 functions among three groups （ P <0.05， P <0.01）； but there was no significant difference in most of QOLIE-31 scores among the three seizure types except seizure worry and drug impact scores ( P >0.05). Conclusions Children with epilepsy have a high risk of comorbid cognitive impairment. The seizure type of children with comorbid cognitive impairment does not affect the characteristics of cognitive impairment. Comorbid cognitive impairment will seriously affect the quality of life of children, so treatment and intervention should be carried out as soon as possible.