Abstract:Objective To investigate the effect of Wuzi Yanzong Pill combined with navel therapy on sperm quality and testosterone level in infertile patients. Methods A total of 186 male infertility patients who received treatment at Reproductive Center of Gaoming Hospital Affiliated to Guangdong Medical University from January 2017 to December 2018 were selected and randomly divided into control group and combination group (n=93, each). The control group was treated with Wuzi Yanzong Pill alone, and the combination group was treated with umbilicus therapy on the basis of the control group. All the patients received 2 courses (60 days a course). The curative effect of the two groups was observed and compared after treatment. The routine parameters of semen quality, the level of serum testosterone and the indexes of superoxide dismutase (SOD), α-glucosidase, fructose, zinc (Zn) and cadmium (Cd) in seminal plasma were detected before and after treatment. Results The total effective rate of the combination group was significantly higher than that of the control group (83.37% vs 55.92%, P<0.05). After two courses of treatment, the patients in the two groups improved significantly in the aspects of forward sperm rate (PR), sperm activity rate, semen concentration, fructose, α-glucosidase, Zn, Cd and serum testosterone level (P<0.05), and the level of SOD improved significantly only in combination group(P<0.05), and the improvements in the combination group were more significant than those in the control group (P<0.05). Conclusion Wuzi Yanzong Pill combined with umbilicus therapy can significantly improve the quality of sperm and seminal plasma and the level of serum testosterone, which could play an important role in improving the pregnancy rate.