Abstract:Objective To investigate the effect of bee acupuncture on pain mediators in lung cancer patients with cancer pain. Methods A total of 86 patients with lung cancer and cancer pain who received treatment from January 2017 to November 2018 were divided into observation group and control group(n=43, each). The control group was treated with paracetamol dihydrocodeine tablets. The observation group was treated with bee acupuncture on the basis of the control group. The total effective rate of the two groups was compared. Visual analogue scale (VAS) was used to evaluate the degree of pain. The onset time and duration of analgesia were recorded. The levels of 5-hydroxytryptamine (5-HT), noradrenaline (NE) and dopamine in serum were measured before and after treatment. The patients′ quality of life was evaluated by Kamofsky Performance Status (KPS). Results The total effective rate of the observation group was significanlty higher than that of the control group (95.35% vs 81.40%, P<0.05). The VAS, 5-HT, NE and dopamine were significant decreased after treatment in both group (all P<0.05), and the VAS, 5-HT, NE and dopamine of the observation group were lower than that of the control group after the treatment (all P<0.05). The onset time of analgesia in the observation group was significantly later than that in the control group, and the duration of analgesia was significantly longer than that in the control group (all P<0.05). The quality of life in the observation group was better than that in the control group (P<0.05). Conclusion Bee acupuncture can improve the effect of lung cancer combined with cancer pain, reduce the release of pain media, and improve the analgesic effect.