Abstract:Objective To explore the clinical efficacy of Tiaogan Yunpi method combined with mesalazine sustained-release granules on diarrhea-predominate irritable bowel syndrome(D-IBS). Methods Total 200 patients with D-IBS were divided into two groups according to the random number table method from September 2016 to November 2017.The control group(n=100) was treated with mesalazine sustained-release granules,and the observation group (n=100) was treated with Tiaogan Yunpi method combined with mesalazine sustained-release granules.The course of treatment was 2 weeks,and the differences in the efficacy,IBS Symptom Severity Scale (IBS-SSS),and IBS Quality of Life Scale (IBS-QOL) scores were compared between the two groups. Results The cure rate (51.00% vs 35.00%,P=0.022) and total effective rate (98.00% vs 81.00%,P=0.000) in the observation group were higher than those in the control group.After treatment,the IBS-SSS score of the observation group decreased from (261.04±76.08) to (122.81±13.81)(P<0.01),and was lower than that of the control group.Except for self-intention,the scores of other dimensions of IBS-QOL in the observation group after treatment were significantly lower than those before treatment（all P＜0.01）,and the scores of all dimensions of IBS-QOL in the observation group after treatment were lower than those in the control group（all P＜0.01）. Conclusion Tiaogan Yunpi method combined with mesalazine sustained-release granules is better than mesalazine in treating diarrhea-type irritable bowel syndrome.