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投稿时间：2019-03-21 网络发布日期：2019-12-23
投稿时间：2019-03-21 网络发布日期：2019-12-23
中文摘要: 目的 观察黄芪注射液联合精蛋白生物合成人胰岛素注射液(预混30R)治疗妊娠期糖尿病(GDM)患者的临床效果。方法 选取2015年7月至2018年7月安康市中心医院收治的120例GDM患者作为研究对象,依据治疗方法不同分两组,各60例。对照组予以精蛋白生物合成人胰岛素注射液治疗,实验组于此基础上予以黄芪注射液治疗。两组均治疗15 d。统计两组妊娠结局,并对比治疗前后血糖［空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)］及血清胱抑素C(Cys-C)、同型半胱氨酸(Hcy)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平。结果 两组治疗后2hPG、HbA1c、FPG水平均较治疗前明显下降,且实验组较对照组低(P<0.05);两组治疗后血清Hcy、Cys-C水平均较治疗前明显下降,且实验组较对照组低(P<0.05);两组治疗后血清MDA、SOD水平均较治疗前明显改善,且实验组血清MDA水平较对照组低,血清SOD水平较对照组高(P<0.05);实验组剖宫产率、妊娠期高血压、新生儿低血糖及巨大儿发生率均较对照组低(P<0.05)。结论 GDM患者采用精蛋白生物合成人胰岛素注射液联合黄芪注射液治疗,可有效控制患者血糖水平,降低血清Hcy、Cys-C、MDA水平,提高SOD水平,改善妊娠结局。
中文关键词: 妊娠期糖尿病 精蛋白生物合成人胰岛素注射液 黄芪注射液 妊娠结局
Abstract:Objective To investigate the clinical effect of astragalus injection combined with protamine biosynthesis human insulin injection (premixed 30R) in the treatment of patients with gestational diabetes mellitus (GDM). Methods A total of 120 patients with GDM treated from July 2015 to July 2018 were enrolled and divided into experimental group and control group according to the different treatment method (n=60,each).The premixed 30R was given in control group,and astragalus injection was added in experimental group based on premixed 30R.The treatment was continued for 15 days in both groups.The pregnancy outcomes,the blood glucose levels before and after treatment ［FPG,2 h postprandial blood glucose (2hPBG),glycosylated hemoglobin (HbA1c)］ and levels of serum cystatin C (Cys-C),homocysteine (Hcy),malondialdehyde (MDA) and superoxide dismutase (SOD) were observed and compared between two groups. Results After treatment,the levels of 2hPG,HbA1c,FPG,Hcy and Cys-C significantly decreased in two groups and were statistically lower in experiment group than those in control group (all P<0.05);compared with control group,serum MDA level decreased,and serum SOD level increased significantly in experiment group（P＜0.05）;the cesarean section rate,the incidences of gestational hypertension,neonatal hypoglycemia and macrosomia were statistically lower in experiment group than those in control group (all P<0.05). Conclusion Premixed 30R combined with astragalus injection can effectively control blood glucose levels,reduce serum Hcy,Cys-C and MDA levels,increase SOD level and improve pregnancy outcomes for GDM patients.
keywords: Gestational diabetes Protamine biosynthesis human insulin injection Astragalus injection Pregnancy outcomes
文章编号： 中图分类号：R 714.25 文献标志码：A
基金项目:陕西省科技厅社会发展科技攻关项目(2016SF-248)
附件
| Author Name | Affiliation |
| CHEN Lin*,CHEN He-ming,YANG Dong | *Department of Obstetrics,Ankang Central Hospital,Ankang,Shaanxi 725000,China |
引用文本：
陈琳,陈鹤鸣,杨栋.黄芪注射液联合精蛋白生物合成人胰岛素注射液(预混30R)治疗妊娠期糖尿病[J].中国临床研究,2019,32(12):1659-1662.
陈琳,陈鹤鸣,杨栋.黄芪注射液联合精蛋白生物合成人胰岛素注射液(预混30R)治疗妊娠期糖尿病[J].中国临床研究,2019,32(12):1659-1662.