Abstract:ObjectiveTo investigate the relationship between serum cholesterol and natural killer cells (NK cells) in patients with acute atherosclerotic cerebral infarction. Methods Sixty-three patients with acute large atherosclerotic cerebral infarction (TOAST classification) hospitalized in the department of neurology of Kaifeng Central Hospital from May 2017 to May 2018 were selected as the study subjects (observation group),and 38 healthy physical examinee were served as normal control group at the same time.Using flow cytometry direct immunofluorescence staining and automatic biochemical analyzer,the levels of peripheral blood NK cells and serum cholesterol were respectively detected and were compared between two groups.The related analysis was made. Results The levels of serum cholesterol and NK cells in peripheral blood in observation group were statistically higher than those in control group (P<0.05,P<0.01).Pearson test showed that there was a positive correlation between serum cholesterol level and peripheral blood NK cell level in patients with acute atherosclerotic cerebral infarction (r=0.179,P=0.011). ConclusionIn patients with acute atherosclerotic cerebral infarction,there is a significant correlation between the level of peripheral blood NK cells and serum cholesterol level,which can provide clinical basis for finding new lipid-regulating drugs.