Abstract:ObjectiveTo explore the clinical characteristics and treatment effect of condyloma acuminatum in children. Methods A total of 48 children with condyloma acuminatum were selected from the outpatient department of Dermatology and Venereology of Guangdong Maternal and Child Health Hospital from October 2013 to September 2017.Medical history inquiry and physical examination were made,and the growth of skin lesions was observed in all patients.The genotype of human papillomavirus (HPV) was detected,and the therapeutic effects of CO₂ laser therapy or CO₂ laser therapy combined with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) were observed. Results There were 37 females (77.08%) and 11 males (22.92%),10 children under 2 years old (20.8%),21 children aged 3-6 years old (43.75%) and 17 children over 6 years old (35.41%).Out of 48 cases,28 cases lived in cities and towns(58.33%),15 cases lived in rural areas(31.25%),and 5 cases lived in urban areas(10.42%).In the risk factors,there were 1 patient with sexual invasion history (2.08%),5 patients with verruca vulgaris history(10.42%),7 patients′ parents or caregivers with verruca vulgaris(14.58%),9 patients′ parents or caregivers with condyloma acuminatum history(18.75%).The above-mentioned risk factors were not inquired out in 26 cases (54.17%).HPV test results showed that 39 cases were positive(81.25%),mainly belonging to a single low-risk type,including 19 cases of HPV6,16 cases of HPV11,2 cases of HPV6+11,1 case for HPV42 and HPV16,and the remaining 9 cases were negative(18.71%).During follow-up period,6 cases were lost,42 cases were cured by CO₂ laser or CO₂ laser combined with ALA-PDT therapy. Conclusion Children′s condyloma acuminatum is predominant in girls,and lesions mainly occur on the perianal area via non-sexual transmission usually.CO₂ laser or CO₂ laser combined with ALA-PDT therapy is effective.