Abstract:Objective To observe the effects of glucocorticoid combined with gamma globulin in the treatment of children with acute Guillain Barre syndrome (GBS).Methods Sixty-eight children with acute GBS admitted to hospital from June 2014 to June 2018 were randomly divided into control group (n=34,treated with gamma globulin alone) and experimental group (n=34,treated with methylprednisolone on the basis of gamma globulin).The time of functional recovery and the serum levels of inflammatory factors were observed and compared between two groups,and the clinical efficacy and adverse reactions were recorded. Results The time to recovery of respiratory muscle paralysis ［(3.79±1.12) d vs (10.27±2.41)d］,the time to recovery of limbs muscle strength ［(5.45±2.07)d vs (17.21±3.53)d］,the time to recovery of extremities pain ［(8.16±2.33) d vs (20.25±4.12)d］ and the time to recovery of sensory disturbance ［(7.21±1.34) d vs (17.45±2.68)d］ in experimental group were significantly shorter than those in control group,respectively (all P<0.01).After treatment,the levels of C-reactive protein(CRP),interleukin -6(IL-6) and tumor necrosis factor-alpha (TNF-α) in both groups were significantly lower than those before treatment (all P<0.01),and CRP［(12.08±4.26)mg/L vs (24.11±4.95)mg/L)］,IL-6［(15.86±4.81)mg/L vs (21.85±6.43)mg/L］ and TNF-α［(20.31±7.84)ng/L vs (27.26±8.13)ng/L］ in experimental group were significantly lower than those in control group (all P<0.01).The total effective rate in experimental group was significantly higher than that in control group (97.06% vs 82.35%,P<0.05). Conclusion Gamma globulin combined with glucocorticoid therapy can effectively improve the clinical symptoms of children with acute GBS,shorten the recovery time of symptoms,inhibit the release of inflammatory factors,and the therapeutic effect is better than that of drug therapy alone.