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投稿时间:2018-01-21 网络发布日期:2018-06-21
投稿时间:2018-01-21 网络发布日期:2018-06-21
中文摘要: 目的 采集汇总血液透析患者的临床质控数据,并据此分析其治疗现状,以期为临床进一步治疗提供参考。方法 对2016年12月至2017年12月在南京南钢医院维持血液透析治疗的72例患者的临床质控数据进行横断面研究,了解临床质控指标总体达标情况,分析糖尿病肾病、透析充分性对临床质控指标的影响。结果 72例维持血液透析患者临床质控指标达标情况如下:溶质清除[尿素下降率(URR)≥65%]达标率47.22%;血压达标率61.11%;血红蛋白(Hb)水平达标率45.83%;营养指标[血白蛋白(ALB)]达标率73.61%;血清Ca2+达标率52.78%;血清P3-达标率58.33%;全段甲状旁腺激素(iPTH)达标率44.44%;微炎症指标[C反应蛋白(CRP)]达标率76.38%。糖尿病肾病患者与非糖尿病肾病患者比较,iPTH、血清P3-、Hb、ALB水平降低,CRP水平升高(P<0.01,P<0.05)。透析达充分性(URR≥65%)患者与透析未达充分性(URR<65%)患者iPTH、P3-、ALB、Hb水平比较,差异均有统计学意义(P<0.01)。结论 在维持血液透析患者,糖尿病肾病比非糖尿病肾病更易发生贫血和营养不良,透析充分性是影响患者iPTH、钙磷代谢水平、营养状态及贫血的重要因素;必须提高透析的充分性,根据临床质控指标的监测,针对不同原发病及检测指标的异常行个体化治疗,以降低并发症,提高患者的生活质量。
Abstract:Objective To summarize the clinical quality control data of hemodialysis patients and analyze the current treatment status to provide evidence for further clinical treatment. Methods The cross-sectional study of clinical quality control data was conducted in 72 maintenance hemodialysis patients treated in Nanjing Nangang Hospital from December 2016 to December 2017. The overall standard-reaching status of clinical quality control indicators was grasped, and the impact of diabetic nephropathy and dialysisadequacy on clinical quality control indicators was analyzed. Results The clinical quality control indicators presented that the standard-reaching rates of solute clearance [urea reduction rate (URR) more than 65%], blood pressure, hemoglobin (Hb) level, nutritional index [serum albumin(ALB)], serum Ca2+, serum P3-, total parathyroid hormone(iPTH), micro inflammation index [C reactive protein (CRP)] were 47.22%, 61.11%, 45.83%, 73.61%, 52.78%, 58.33%, 44.44% and 76.38% respectively. In diabetic nephropathy patients, the levels of iPTH, serum P3-, Hb and ALB decreased significantly, and the CRP level increased compared with non-diabetic nephropathy patients(P<0.01, P<0.05). There were significant differences in the levels of iPTH, P3-, ALB and Hb between the patients with dialysis adequacy(URR>65%) and the patients with dialysis inadequacy(URR<65%)(all P<0.01). Conclusion In maintenance hemodialysis patients, anemia and malnutrition are more likely to occur in diabetic nephropathy patients, and dialysis adequacy is an important factor affecting iPTH level, calcium and phosphorus metabolism, nutritional status and anemia. It is necessary to improve dialysis adequacy based on the monitoring of clinical quality control indicators. According to different primary diseases and abnormality of detection indexes, individualized treatment should be performed to reduce complications and improve the quality of life of patients.
keywords: Hemodialysis Hemodialysis adequacy Diabetic nephropathy Malnutrition Anemia Calcium and phosphorus metabolism Parathyroid hormone Micro inflammatory state
文章编号: 中图分类号:R 459.5 文献标志码:B
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附件
Author Name | Affiliation |
YANG Shu-ping*, XUE Jing-song, DAI Xiao-ping, CHEN Wen-jun, FANG Fang | Hemodialysis Center, Nanjing Nangang Hospital, Nanjing, Jiangsu 210035, China |
引用文本:
杨书平,薛劲松,戴晓萍,陈文君,方芳.维持血液透析患者临床质控指标分析[J].中国临床研究,2018,31(6):809-812.
杨书平,薛劲松,戴晓萍,陈文君,方芳.维持血液透析患者临床质控指标分析[J].中国临床研究,2018,31(6):809-812.