Abstract:Objective To investigate the effect of intraductal infusion of urokinase(UK) in the treatment of catheter thrombosis with tunnel and polyester sleeve. Methods Sixteen patients with ineffective intraductal UK thrombolysis from July 2015 to October 2016 were selected, and UK infusion pump therapy ( 250 thousand U plus 100 ml normal saline pumped into catheter at 10 ml/h speed from the catheter′s arteriovenous ends at the same time) were given for 5 hours. The blood flow, arterial pressure and venous pressure of pipeline were observed before and after thrombolysis. Results After infusion pump of urokinase, the patency rate was 100%. Compared with pre-thrombolysis, the blood flow [(271.25± 10.25) ml/min vs (93.13±22.72) ml/min], pipeline arterial pressure [(11.63±2.91) mm Hg vs (45.08±11.27) mm Hg], and pipeline venous pressure [(13.01±3.25) mm Hg vs (5.64±1.41)mm Hg] significantly improved after infusion pump of urokinase(all P<0.01), which were in compliance with evaluation criteria of unobstructed catheter. There were no significant differences in prothrombin time, partial thromboplastin time, levels of alanine aminotransferase and aspartate aminotransferase before and after thrombolysis(all P>0.05). Conclusion Infusion pump of urokinase is effective and safe in the treatment of catheter thrombosis with tunnel and polyester sleeve.