Abstract:Objective To observe the influences of climen (composite packaging of estradiol valerate tablets and estradiol cyclopropyl progesterone)combined with triptorelin on serum sex hormone and adverse reactions in patients with endometriosis.? Methods A total of 70 patients with confirmed endometriosis, who received laparoscopic conservative surgical treatment from January 2014 to January 2016, were selected as study objects and divided into combined group and control group by random number table method(n=45, each). Intramuscular injection of 3. 75 mg triptorelin was given at 3-5 days after operation in control group, and oral administration of climen was given based on the treatment perscription of control group in combined group. All patients were treated continuously for 4 to 6 months. The serum levels of estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were detected by enzyme-linked immunosorbent assay, and the degree of pain and menopausal symptoms were evaluated using visual analogue scale (VAS)and Kuppperman score before and after treatment. After completing treatment, the patients were followed up for 6 months in whom the pregnancy and recurrence were compared between two groups.? Results The serum levels of E2, FSH and LH before treatment were significantly lower than those after treatment in both two groups (all P<0.01). Compared with control group, levels of E2 and LH increased, and FSH level decreased after treatment in combined group (all P<0.01).? The VAS were all decreased after treatment in two groups, the Kuppperman score was increased in control group, and the scores of VAS and Kuppperman in combined group were significantly lower than those in control group after treatment (all P<0.01). There were no significant differences in pregnancy rate and recurrence rate between two groups(all P>0.05).? Conclusion Combined application of climen and triptorelin can effectively adjust the serum estrogen levels in treatment for patients with triptorelin, reducethe adverse reactions caused by low estrogen levels following triptorelin alone without affecting the clinical efficacy.