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Received:October 24, 2024 Published Online:June 20, 2025
Received:October 24, 2024 Published Online:June 20, 2025
中文摘要: 妇科恶性肿瘤发病率长期居高不下，目前的治疗手段主要以全身麻醉下的肿瘤切除为主。丙泊酚被广泛用于全身麻醉的诱导和维持。丙泊酚对妇科恶性肿瘤患者预后具有重要的影响，然而其具体机制不清楚。目前的研究表明，丙泊酚可通过调控细胞结构、自噬、化疗药物的敏感性，以及通过微小RNA（miRNA）、环状RNA（circRNA）、长链非编码RNA（lncRNA）和Yes相关蛋白（YAP）通路及人体自身免疫系统等途径改善妇科恶性肿瘤预后的作用。因此，本文对丙泊酚对妇科恶性肿瘤患者预后的影响及其机制，包括丙泊酚对细胞结构、自噬、化疗药物的敏感性调控，以及经miRNA、circRNA、lncRNA和YAP通路等发挥作用的机制作一综述。
Abstract:The incidence of gynecologic malignancies remains persistently high，with current treatment primarily focusing on tumorresection under general anesthesia. Propofol is widely used for induction and maintenance of general anesthesia. It significantly impactsthe prognosis of patients with gynecologic malignancies，yet its specific mechanisms are not well understood. Current research indicatesthat propofol may improve the prognosis of gynecologic malignancies through mechanisms such as modulation of cell structure，autophagy，sensitivity to chemotherapy，as well as microRNA（miRNA），circular RNA（circRNA），long non?coding RNA（lncRNA），Yes ? associated protein（YAP）pathways，and autoimmune system. Therefore，this review summarizes the effects of propofol on theprognosis of patients with gynecologic malignancies，focusing on its regulation of cell structure，autophagy，sensitivity to chemotherapy，and mechanisms involving miRNA，circRNA，lncRNAs，and YAP pathways.
keywords: Propofol Gynecologic malignancy Autophagy Chemotherapy drugs MicroRNA Circular RNA Long non⁃coding RNA
文章编号： 中图分类号：R614 R737.31 文献标志码：A
基金项目:国家自然科学基金（8186020335）；贵州省科技厅项目（黔科合基础?ZK［2022］一般664）；遵义市联合基金［遵市科合HZ（2021）84号］；广东省基础与应用基础研究基金项目（2024A1515012880）
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