Abstract:Obstructive sleep apnea hypopnea syndrome(OSAHS)is characterized by chronic intermittent hypoxia and fragmented sleep,which are its main pathophysiological features,thus making it a risk factor for the development of metabolic diseases.OSAHS is associated with the occurrence and development of a variety of metabolic diseases,and insulin resistance is the pathophysiological basis of chronic metabolic diseases such as type 2 diabetes and atherosclerosis.Clinical studies have shown that OSAHS is independently associated with insulin resistance,and basic research has also confirmed that chronic intermittent hypoxia promotes the development of insulin resistance.This article will review the correlation between OSAHS and insulin resistance,their mechanisms of occurrence,as well as clinical treatment to improve scientific assessment and integrated management of insulin resistance in patients with OSAHS.