Abstract:Objective To compare the effects of holmium laser enucleation of the prostate (HoLEP) with different laser parameters on patients with benign prostatic hyperplasia (BPH). Methods The clinical data of 110 patients with BPH who underwent HoLEP in the First Hospital of Qiqihar from June 2021 to June 2023 were retrospectively analyzed. Patients were divided into group A (37 cases), group B (37 cases) and group C (36 cases) according to the parameters of Holmium laser. Group A underwent 45 W(1.5 J×30 Hz) HoLEP; in group B, 60 W(2.0 J×30 Hz) HoLEP was performed. Group C was treated with 80 W(2.0 J×40 Hz) HoLEP. The operation-related indexes and postoperative complications of each group were compared. The improvement of international prostate symptom score (IPSS), quality of life (QOL), maximum urine flow rate (Qmax) and postoperative residual urine volume (PVR) were compared before and 3 months after operation. Results There was no significant difference in operation-related indexes among groups A, B and C (P＞0.05). IPSS score, QOL score and PVR of patients in group A, B and C 3 months after operation were lower than those before operation, and Qmax was higher than that before operation (P＜0.05). While 3 months after operation, there was no significant difference in IPSS score, QOL score, PVR and Qmax among group A, B and C (P＞0.05). There was no significant difference in the incidence of complications among the three groups (P＞0.05). Conclusion 45 W, 60 W low-power HoLEP is equivalent to 80 W high-power HoLEP, and there is no significant difference in operation time, hospital stay, indwelling time of catheter, enucleation quality and enucleation efficiency, and both have good hemostasis effect and safety.