Abstract:Objective To investigate the relationship between the triglyceride-glucose (TyG) index and major adverse cardiovascular and cerebrovascular events (MACEs) in acute coronary syndrome (ACS) patients and evaluate the potential value of TyG index in predicting MACEs.Methods From January 2019 to December 2022，a total of 270 ACS patients who underwent coronary intervention in Jinling Hospital, Medical School of Nanjing University were included and followed up for a period of 36 months. According to the quartiles of TyG, the patients were divided into very low TyG group (TyG≤9.32, 69 cases), low TyG group (TyG 9.33-9.60, 66 cases), medium TyG group (TyG 9.61-9.84, 68 cases) and high TyG group (TyG≥9.85, 67 cases). The relationship between the baseline data of patients in different TyG groups was analyzed. Logistic regression was used to evaluate the correlation between TyG index and MACEs, and ROC curve was used to evaluate the predictive efficiency of TyG index on MACEs. Results Compared with the other three groups, the patients in the high TyG group had significantly higher levels of uric acid, total cholesterol, high-density lipoprotein and low-density lipoprotein, and the risk of cardiac death (P＜0.05). Univariate logistic regression showed that high TyG index was a risk factor for all-cause death, cardiac death and congestive heart failure (P＜0.01). ROC curve analysis confirmed that the area under the ROC curve of TyG index for the predicting all-cause death, cardiac death and congestive heart failure were 0.724 (95%CI:0.689-0.758), 0.730 (95%CI:0.695-0.763) and 0.662 (95%CI:0.625-0.698), respectively. Conclusion Elevated TyG index has certain diagnostic value for the occurrence of MACEs in ACS patients.