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Received:October 11, 2024 Published Online:February 20, 2025
Received:October 11, 2024 Published Online:February 20, 2025
中文摘要: 丁型肝炎病毒（hepatitis D virus, HDV）感染是一个严重的公共卫生问题，HDV是一种有缺陷的RNA病毒，需要借助乙型肝炎病毒（hepatitis B virus, HBV）才能实现感染和复制。与单独HBV感染相比，合并HDV感染的HBV感染者病情更严重、疾病进展更快，发生肝硬化、肝癌的风险也明显增加。本文总结了HDV的病毒学、流行病学等进展及目前我国面临的主要挑战，以期推动我国关于丁型肝炎的研究。
Abstract:Hepatitis D virus (HDV) infection is a major global public health problem. HDV is a defective subvirus that requires the hepatitis B virus (HBV) for assembly and propagation. Compared to HBV-monoinfected patients, individuals with HDV coinfection experience a more rapid progression to advanced liver disease, including cirrhosis and hepatocellular carcinoma. This review emphasizes the recent advances in HDV virology, epidemiology and the challenges in China to search the opportunities that can move this field forward.
文章编号： 中图分类号：R181.3 R512.6 文献标志码：A
基金项目:北京市医院管理中心“登峰”人才培养计划（DFL20221501）；北京市高层次公共卫生技术人才培养计划（学科带头人-01-12）
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