Abstract:Objective To compare the efficacy of Indigo mechanical thrombectomy and catheter-directed thrombolysis (CDT) in the treatment of acute deep vein thrombosis (DVT) of the lower extremity. Methods A retrospective analysis was conducted on the clinical data of 108 patients with acute lower extremity DVT treated at Xuzhou Central Hospital from December 2022 to December 2023. According to the treatment method, patients were divided into two groups. The control group consisted of 57 patients who received CDT treatment, while the experimental group consisted of 51 patients who underwent Indigo mechanical thrombectomy. Postoperative venous patency scores, postoperative venous patency rates, swelling reduction rates of the affected limbs, thrombus clearance grades, dosages of urokinase, thrombolytic times, and hospital stays were compared between the two groups.Results The postoperative venous patency score in the experimental group was lower than that in the control group (1.63±1.00 vs 2.35±1.08), while the venous patency rate ［(78.97±13.04)% vs (68.07±14.25)%］ and the swelling reduction rate ［(72.31±11.70)% vs (65.68±8.27)%］ were higher in the experimental group compared to the control group, with statistically significant differences (P＜0.05). The dosage of urokinase in the experimental group ［(146.08±35.85)×10⁴ units vs (308.42±45.33)×10⁴ units］ was lower than in the control group, and the thrombolysis time ［(2.39±0.78)days vs (5.11±0.82)days］ and hospital stays ［(8.37±0.96) days vs (10.37±1.10) days］ were shorter in the experimental group, with statistically significant differences (P＜0.05). No significant difference was observed between the two groups in terms of thrombus clearance grading (P＞0.05). Follow-up time ranged from 6 to 18 months, and all patients with implanted stents had patent stents without any occurrence of stenosis or occlusion. Conclusion Compared to CDT, the Indigo mechanical thrombectomy treatment regimen has more significant advantages, including reducing the use of thrombolytic drugs, shortening treatment time, improving thrombolytic effects, and being easy to operate.