Abstract:Objective To explore the application of comprehensive geriatric assessment (CGA)-based comprehensive nursing intervention combined with rehabilitation training in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Methods A total of 204 patients with AMI admitted to the First Affiliated Hospital of Soochow University from January 2021 to May 2023 were included in the study. Patients were divided into routine group and CGA group by using the random number table method, with 102 cases in each group. The routine group was given routine nursing and rehabilitation training, while the CGA group was given CGA-based comprehensive nursing intervention and rehabilitation training. The cardiopulmonary reserve function [peak oxygen consumption (VO₂max) and anaerobic threshold oxygen consumption (VO₂AT), and carbon dioxide ventilation equivalent slope (VE/VCO₂)], psychological status [using Hamilton Anxiety Scale (HAMA)], compliance behaviors and quality of life [China Questionnaire of Quality of Life in patients with cardiovascular diseases (CQQC)] before and after intervention and incidence rates of major adverse cardiovascular events (MACE) within half a year were compared between the two groups. Results After intervention, the VO₂max and VO₂AT in both groups were significantly increased (P＜0.01) while the VE/VCO₂ was significantly decreased (P＜0.01). The VO₂max and VO₂AT in CGA group were significantly higher (P＜0.05) while the VE/VCO₂ was significantly lower compared to routine group (P=0.025). The HAMA scores in the two groups were reduced significantly after intervention (P＜0.01), and the CGA group had significantly lower scores (P＜0.01). After intervention, the three compliance behaviors of balanced nutrition, abstaining from bad habits and healthy exercise were significantly better in CGA group than those in routine group (P＜0.05). The CQQC scores in the two groups after intervention were significantly increased (P＜0.01), and the scores in CGA group were significantly higher (P＜0.01). There was no statistical difference in the incidence increased of MACE between both groups within half a year (1.96% vs 3.92%, χ²=0.687, P=0.407). Conclusion CGA-based comprehensive nursing intervention combined with rehabilitation training can significantly improve the cardiopulmonary reserve function of AMI patients after PCI, and enhance the negative emotions, compliance behaviors and quality of life.