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Received:June 14, 2024 Published Online:December 21, 2024
Received:June 14, 2024 Published Online:December 21, 2024
中文摘要: 目的 探讨不同病程的2型糖尿病（T2DM）患者胰岛β细胞功能与铁代谢指标之间的相关性。方法 纳入2023年5月至2023年8月南京梅山医院内分泌科就诊的120例T2DM患者及同时期江苏省人民医院体检中心的120例健康人群行横断面研究。比较T2DM患者及健康人群的临床资料及实验室指标。根据糖尿病病程分为0~＜5年为A组(38例)，5~＜10年为B组(45例)，≥10年为C组(37例)，比较三组之间临床资料的差异。采用Pearson相关分析法分析胰岛β细胞功能与一般资料、铁代谢指标、糖脂代谢指标的相关性，采用多重线性回归分析法分析不同病程的T2DM患者胰岛β细胞功能指数（HOMA-β）与血清铁(SI)、血清铁蛋白(SF)、血清转铁蛋白（Trf）、血清转铁蛋白饱和度(TS)的关系。结果 T2DM组SF水平高于健康对照组 [（199.88±10.73）ng/mL vs （164.46±9.69）ng/mL, P＜0.05＝。Pearson相关性分析显示HOMA-β与BMI、SI及TS正相关，与糖化血红蛋白（HbA1c）和lg(SF)负相关(P＜0.01＝。多重线性回归分析显示，调整协变量后，A组Homa-β与lg(SF)(β=-62.00, 95%CI: -79.12~-44.87, P＜0.01＝负相关，与TS(β=1.03， 95%CI: 0.37~1.70，P＜0.05)和Trf(β=31.24，95%CI: 5.56~56.92， P＜0.05)正相关；B组HOMA-β与TS(β=1.50， 95%CI: 0.25~2.76，P＜0.05)正相关；C组HOMA-β与铁代谢指标无相关。结论 T2DM患者胰岛β细胞功能随着病程的延长而逐渐下降，存在铁代谢紊乱。短病程T2DM患者胰岛β细胞功能障碍与铁代谢指标SF、Trf和TS相关。
Abstract:Objective To explore the correlation between pancreatic β-cell function and iron metabolism markers in patients with type 2 diabetes mellitus (T2DM) at different disease durations. Methods A cross-sectional study was conducted on 120 T2DM patients from the Department of Endocrinology at Nanjing Meishan Hospital and 120 healthy individuals from the Physical Examination Center of Jiangsu Province People’s Hospital during the same period from May 2023 to August 2023. Clinical data and laboratory indicators were compared between T2DM patients and healthy individuals. Patients were divided into three groups based on disease duration: group A (0-＜5 years, 38 cases), group B (5-＜10 years, 45 cases), and group C (≥10 years, 37 cases), and the differences in clinical data among the three groups were compared. Pearson correlation analysis was used to analyze the correlation between pancreatic β-cell function and general information, iron metabolism indicators, and glycolipid metabolism indicators. Multiple linear regression analysis was used to analyze the relationship between pancreatic β-cell function index (HOMA-β) and serum iron (SI), serum ferritin (SF), serum transferrin (Trf), and transferrin saturation (TS) in T2DM patients with different disease durations. Results The SF level in the T2DM group was higher than that in the healthy control group [(199.88±10.73)ng/mL vs (164.46±9.69)ng/mL, P＜0.05]. Pearson correlation analysis showed that Homa-β was positively correlated with BMI, SI, and TS and negatively correlated with glycosylated haemoglobin(HbA1c) and lg (SF) (P＜0.01). Multiple linear regression analysis showed that after adjusting for covariates, HOMA-β in group A was negatively correlated with lg (SF) (β=-62.00, 95%CI: -79.12 to -44.87, P＜0.01) and positively correlated with TS (β=1.03, 95%CI: 0.37 to 1.70, P＜0.05) and Trf (β=31.24, 95%CI: 5.56 to 56.92, P＜0.05), and group B HOMA-β was positively correlated with TS (β=1.50, 95%CI: 0.25 to 2.76, P＜0.05); Group C Homa-β showed no correlation with iron metabolism indicators. Conclusion Pancreatic β-cell function in T2DM patients gradually declines with disease duration, accompanied by iron metabolism disorders. Pancreatic β-cell function in T2DM patients with a short disease duration is associated with iron metabolism indicators SF, Trf, and TS.
keywords: Type 2 diabetes mellitus Pancreatic β-cell function Insulin resistance index Iron metabolism Ferritin Transferrin
文章编号： 中图分类号：R587.1 文献标志码：A
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