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中国临床研究英文版:2024,37(10):1521-1525
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彩色多普勒超声联合三种血清因子诊断乳腺癌的临床价值
(1. 武汉科技大学附属汉阳医院超声科,湖北 武汉 430050;2. 华中科技大学同济医学院附属协和医院超声科,湖北 武汉 430022;3. 华中科技大学同济医学院附属协和医院检验科,湖北 武汉 430022)
Clinical value of color Doppler ultrasound combined with three serum factors in diagnosis of breast cancer
摘要
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Received:August 02, 2024   Published Online:October 20, 2024
中文摘要: 目的 探讨在彩色多普勒超声(CDU)检测的基础上联合血清糖类抗原(CA)125、富半胱氨酸蛋白61(CYR61)、胰岛素样生长因子-1(IGF-1)对乳腺癌的临床诊断效能。 方法 将2021年1月至2023年12月于武汉科技大学附属汉阳医院诊治的86例女性乳腺癌患者纳入乳腺癌组,将同期治疗的女性乳腺良性疾病患者86例纳入良性组,两组均行CDU与血清CA125、CYR61、IGF-1检测。分析两组以及乳腺癌组不同TNM分期患者CDU特征和血清CA125、CYR61、IGF-1水平。ROC曲线分析CDU、血清CA125、CYR61、IGF-1单独及联合诊断乳腺癌的效能。 结果 乳腺癌组病灶边界不清、形态不规则、微钙化、内部回声不均匀、高分级血流信号占比及阻力指数(RI)、搏动指数(PI)、收缩期峰值流速(PSV)均高于良性组(P<0.05);血清CA125、CYR61、IGF-1水平均高于良性组(P<0.01)。乳腺癌组Ⅰ~Ⅱ期患者血清CA125、CYR61、IGF-1水平均低于Ⅲ期患者(P<0.01)。ROC曲线分析显示,CDU及血清CA125、CYR61、IGF-1四项及其联合诊断乳腺癌的曲线下面积(AUC)分别为0.874、0.832、0.849、0.806和0.962,以联合诊断的AUC最高,特异度(95.29%)、敏感度(93.86%)也最高。 结论 CDU联合血清CA125、CYR61、IGF-1诊断乳腺癌具有较高的临床价值。
Abstract:ObjectiveTo investigate the clinical diagnostic efficacy of color Doppler ultrasound (CDU) combined with serum carbohydrate antigen (CA) 125, cysteine-rich protein 61 (CYR61) and insulin-like growth factor-1 (IGF-1) for breast cancer. Methods Eighty six female breast cancer patients treated in Hanyang Hospital Affiliated to Wuhan University of Science and Technology from January 2021 to December 2023 were included in the breast cancer group, and 86 female benign breast disease patients treated in the same period were included in the benign group for retrospective analysis. CDU and serum CA125, CYR61, IGF-1 were detected in both groups. The CDU characteristics and serum CA125, CYR61 and IGF-1 levels of patients in the two groups, and those of breast cancer patients with different TNM grades were analyzed. ROC curve was used to analyze the diagnostic efficacy of CDU, serum CA125, CYR61 and IGF-1 for breast cancer alone and in combination. Results Compared with benign group, the proportions of unclear boundaries, irregular morphology, microcalcification, uneven internal echo, and high-grade blood flow signals, as well as resistance index (RI), pulsatility index (PI), 〖JP2〗and peak systolic velocity (PSV) values in breast cancer group were higher (P<0.05).The levels of serum CA125, 〖JP+1〗CYR61, and IGF-1 all increased in breast cancer group〖JP〗 compared〖LM〗 to benign group (P<0.01). ROC curve analysis showed that the area under the curve (AUC) of CDU, serum CA125, CYR61, IGF-1 and their combined diagnosis of breast cancer were 0.874, 0.832, 0.849, 0.806 and 0.962, respectively,with the highest AUC, specificity (95.29%) and sensitivity (93.86%) in combined diagnosis of four indexes. Conclusion CDU combined with serum CA125, CYR61 and IGF-1 has a high clinical value in the diagnosis of breast cancer.
文章编号:     中图分类号:R737.9    文献标志码:A
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