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Received:December 16, 2023 Published Online:September 20, 2024
Received:December 16, 2023 Published Online:September 20, 2024
中文摘要: 目的 探讨银杏叶片对不稳定型心绞痛患者的疗效及对成纤维细胞生长因子4（FGF-4）的影响。方法 选取2022年1月至2023年9月于连云港市第一人民医院接受治疗的360例不稳定型心绞痛患者，根据Gensini评分分为低危组（Gensini积分1~30分，n=112）、中危组（Gensini积分31~60分，n=156）及高危组（Gensini积分61~90分，n=92），再将每组患者随机均分为观察组与对照组。对照组按冠心病标准治疗方案，观察组在对照组基础上联用银杏叶片治疗。治疗4周后，比较不同分组患者FGF-4、炎症因子水平，心绞痛发作次数及持续时间，不稳定型心绞痛严重程度分级（Braunwald分级）。结果 治疗后，低危观察组和中危观察组患者外周血清FGF-4水平均高于其相应的对照组（P＜0.05），高危观察组较其对照组FGF-4水平有升高趋势，但差异无统计学意义（P＞0.05）。3个观察组患者肿瘤坏死因子白细胞介素（TNF）-α、白细胞介素（IL）-2、IL-6水平均低于其相应的对照组（P＜0.05）。治疗后，低危观察组与中危观察组患者心绞痛发作次数、持续时间均低于相应的对照组（P＜0.05），高危组观察组与其对照组比较差异无统计学意义（P＞0.05）。治疗后观察组与对照组不良反应发生率差异无统计学意义（P＞0.05）。结论 银杏叶片能够改善不稳定型心绞痛患者的临床疗效，缓解临床症状，其作用机制可能与其通过升高FGF4水平，进而降低TNF-α、IL-2、IL-6炎症因子水平，发挥抗炎作用相关。
中文关键词: 银杏叶片 心绞痛，不稳定型 成纤维细胞生长因子4 Gensini评分
Abstract:Objective To explore the therapeutic effect of Ginkgo biloba tablets on patients with unstable angina and their impact on fibroblast growth factor 4 (FGF-4). Methods From January 2022 to September 2023, 360 patients with unstable angina who received treatment in Lianyungang First People's Hospital were selected and divided into low-risk group (Gensini score 1-30, n=112), medium risk group (Gensini score 31-60, n=156), and high-risk group (Gensini score 61-90, n=92) based on Gensini score. Each group of patients were randomly divided into an observation group and a control group. The control group was treated with standard treatment plan for coronary heart disease, while the observation group was treated with Ginkgo biloba tablets in addition to the control group. After 4 weeks of treatment, the levels of FGF-4 and inflammatory factors, the frequency and duration of angina attacks, and the severity of unstable angina (Braunwald classification) were compared between the different groups. Results After treatment, the peripheral serum FGF-4 levels of patients in the low-risk observation group and the medium risk observation group were higher than their corresponding control groups (P＜0.05). The high-risk observation group showed an increasing trend in FGF-4 levels compared to its control group, but the difference was not statistically significant (P＞0.05). The average levels of tumor necrosis factor (TNF)-α, interleukin (IL)-2, and IL-6 in the three observation groups were lower than those in the corresponding control group (P＜0.05). After treatment, the frequency and duration of angina attacks in the low-risk observation group and the medium risk observation group were lower than those in the corresponding control group (P＜0.05), while there was no statistically significant difference between the high-risk observation group and its control group (P＞0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group after treatment (P＞0.05). Conclusion Ginkgo biloba leaves extract tablets can improve the clinical efficacy and alleviate clinical symptoms in patients with unstable angina pectoris. Its mechanism may be related to its anti-inflammatory effect by increasing FGF-4 levels, thereby reducing the levels of TNF-α, IL-2, and IL-6 inflammatory factors.
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基金项目:连云港市第一人民医院中西医结合科研项目（ZX09）；南京医科大学康达学院科研发展基金项目（KD2021KYJJZD104）
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