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Received:August 16, 2023 Published Online:June 20, 2024
Received:August 16, 2023 Published Online:June 20, 2024
中文摘要: 目的 基于大样本队列研究探讨中老年人心脏代谢指数(CMI)与脑卒中之间的关系。方法 数据来源于2011年至2018年的中国健康与养老追踪调查(CHARLS)。建立多变量logistic回归模型探究CMI与脑卒中之间的关联,同时采用限制立方样条模型(RCS)来检查可能的非线性关联。结果 本研究共纳入6 198例研究对象,7年的随访中发生脑卒中349例,基线CMI的水平为0.98(0.61, 1.51)。Logistic回归结果发现,CMI每上升一个四分位数,新发生脑卒中的患病风险增加36.7%(OR=1.367, 95%CI:1.188~1.574),并且存在累积效应(线性趋势检验P<0.01)。RCS结果发现CMI与脑卒中存在剂量-反应关系(P<0.01)且为非线性关系(Pnon-linear<0.01)。结论 高水平的CMI对脑卒中的发生有较高的预测价值。
Abstract:Objective To explore the relationship between cardiac metabolic index (CMI) and stroke in middle-aged and elderly individuals based on a large sample cohort study. Methods Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018. Multivariate logistic regression models were developed to explore the association between CMI and stroke, while restricted cubic spline (RCS) model was used to examine possible non-linear associations. Results A total of 6198 study participants were included in this study, with 349 strokes occurring during the 7-year follow-up and a baseline CMI level of 0.98 (0.61, 1.51). Logistic regression results showed that for each quartile increase in CMI, the prevalence risk of a new stroke was increased by 36.7% (OR=1.367, 95%CI: 1.188-1.574) and there was a cumulative effect (P for trend<0.01). RCS showed that there was a dose-response relationship between CMI and stroke (P<0.01), and it was a non-linear relationship (Pnon-linear<0.01). Conclusion High levels of CMI have a high predictive value for the occurrence of stroke.
文章编号: 中图分类号:R743.33 文献标志码:A
基金项目:辽宁省教育厅科学研究经费资助项目(FWZR2020004)
Author Name | Affiliation |
YU Yang, SHA Ou | Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shengyang, Liaoning 110001, China |
Author Name | Affiliation |
YU Yang, SHA Ou | Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shengyang, Liaoning 110001, China |
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