Abstract:In recent years, minimally invasive spine surgery (MISS) has gradually become a feasible, highly effective and popular method for the treatment of various spinal diseases. Compared to traditional open surgery, MISS has many advantages, such as less trauma, faster recovery, and fewer complications. The application of computer navigation technology in MISS enables the rapid development of navigation assisted minimally invasive spine surgery (NAMISS), which significantly improves the accuracy of spinal implants such as pedicle screws, and increases patient safety. In addition, the technology has the potential to improve biomechanical properties while also reducing radiation exposure and dose and helping to mitigate the long-term harmful effects of ionizing radiation. This paper reviews the development status of NAMISS mainly from four aspects: technical progress, clinical application, challenges and future development direction.