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Received:January 29, 2024 Published Online:April 20, 2024
Received:January 29, 2024 Published Online:April 20, 2024
中文摘要: 氯胺酮是常用的麻醉药物，但是由于术后噩梦、锥体外系综合征以及滥用倾向等问题，其在20世纪90年代后期的临床应用有所减少。而艾司氯胺酮作为氯胺酮的异构体，与消旋体氯胺酮相比，应用剂量较小，具有较强的镇痛和镇静作用，心血管和精神方面不良反应小。其代谢快，在体内清除率高，对患儿呼吸循环影响轻微，苏醒和恢复迅速，在小儿麻醉效果方面有显著的应用价值。
中文关键词:
Abstract:Ketamine is a commonly used anesthetic drug, but its clinical use declined in the late 1990s due to its postoperative nightmares, extrapyramidal syndrome, and a tendency to abuse. As an isomer of ketamine, esketamine is applied in a smaller dose than racemic ketamine, with strong analgesic and sedative effects, fewer cardiovascular and psychiatric adverse reactions. It has a significant application value in pediatric anesthesia with fast metabolism and high clearance rate in vivo, slight impact on childrens respiratory and circulation, and rapid awakening and recovery.
keywords: Esketamine Children Sedation Diagnostic procedures Anesthesia induction Pre-hospital emergency analgesia Postoperative analgesia
文章编号： 中图分类号：R971.1 文献标志码：A
基金项目:国家自然科学基金（81860233）;甘肃省科技计划项目（21JR7RA621，21JR7RA675）
| Author Name | Affiliation |
| WANG Lu*, YAN Wenjun | *The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, China |
| 阎文军1,2 | 1. 兰州大学第一临床医学院，甘肃 兰州 730000；2. 甘肃省人民医院麻醉科，甘肃 兰州 730000 |
| Author Name | Affiliation |
| WANG Lu*, YAN Wenjun | *The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, China |
| 阎文军1,2 | 1. 兰州大学第一临床医学院，甘肃 兰州 730000；2. 甘肃省人民医院麻醉科，甘肃 兰州 730000 |
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