Abstract:Inhalation anesthetics have both sedative, analgesic and muscle relaxing effects,and are widely used in clinical practice. Hypersensitivity to inhalation anesthetics predicts poor postoperative outcomes. Current studies have shown that some genetic mutations, ion channels or receptors, changes in metabolites, mitochondrial function are associated with the sensitivity of human or experimental animals to inhalation anesthetics. Therefore, this paper will briefly review the research progress in the mechanism of inhalation anesthetics sensitivity from gene mutation, ion channels or receptors, metabolites, and mitochondrial function.