Abstract:Objective To study the application effect of the pre-hospital and in-hospital medical linkage system in emergency care of ischemic stroke patients. Methods The observation group consisted of patients diagnosed with acute ischemic stroke and treated with thrombolysis through the pre-hospital and in-hospital medical linkage system from January 1, 2022 to March 31, 2023 (n=117), and the control group consisted of stroke patients under routine emergency treatment from January 1, 2021 to March 31, 2021 (n=109). The patient identification time, patient transport time, pre-hospital to in-hospital time, door to needle time (DNT), hospital stay, incidence of complications, mortality, Barthel index, and NIHSS score were compared between two groups. Results Compared with the control group, the observation group had shorter pre-hospital and in-hospital transition time, DNT, and hospital stay (P<0.05). The total incidence of complications in the control group was higher than that in the observation group (44.95% vs 20.51%， χ²=15.415, P<0.05). After treatment, the Barthel index of the observation group was higher than that of the control group, and the NIHSS score was lower than that of the control group, with statistical significance (P<0.05). Conclusion The application of pre-hospital and in-hospital linkage system in emergency care of ischemic stroke patients has a significant effect, which can shorten DNT, reduce complications, and effectively improve patients' daily living ability and neurological function recovery.