Abstract:The intestinal mucosal barrier is a unified structure and function that maintains the stability of the internal environment of the organism, consisting of mechanical, chemical, immune, and biological barriers. Each barrier has corresponding structural foundations, which selectively absorb water and nutrients in a dynamically changing form during the body's digestion process by exerting their respective biological functions, preventing intestinal bacterial ectopia, exerting intestinal immune function, and assisting the body in maintaining intestinal integrity and immune homeostasis. Non-steroidal anti-inflammatory drugs (NSAIDs) can damage the intestinal barrier by altering various inflammatory mediators and pathological processes in the body.At present, studying intestinal barrier dysfunction has become a hot topic in the field of medical research. This article reviews the mechanism and prevention and treatment progress of intestinal mucosal barrier function damage caused by NSAIDs, aiming to provide reference for the prevention and treatment of intestinal mucosal damage caused by NSAIDs.