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Received:November 02, 2023 Published Online:February 20, 2024
Received:November 02, 2023 Published Online:February 20, 2024
中文摘要: 胃癌发病率及死亡率均位于肿瘤前列，且预后差，尤其是中晚期胃癌，即便采取了综合治疗，5年生存率也很低。精准医疗的发展延长了患者的生存期，成纤维细胞生长因子受体（FGFR）已逐渐成为胃癌治疗的热门靶点。本文就胃癌中常见的FGFR改变类型和近年FGFR抑制剂在胃癌领域中的探索进行综述，并对面临的挑战进行分析。
中文关键词: 成纤维细胞生长因子受体 胃癌 成纤维细胞生长因子抑制剂 酪氨酸激酶抑制剂 配体陷阱 单克隆抗体 基因扩增 基因突变 基因重排
Abstract:The incidence and mortality of gastric cancer are in the forefront of the tumor, and the prognosis is poor, especially in the middle and advanced stage. Even with comprehensive treatment, the 5- year survival is very low. The development of precision medicine has extended the survival of patients, and fibroblast growth factor receptor (FGFR) has gradually become a popular target for the treatment of gastric cancer. In this paper, the common FGFR alteration types in gastric cancer and the exploration of FGFR inhibitors in the field of gastric cancer were reviewed, and the challenges were analyzed.
keywords: Fibroblast growth factor receptor Gastric cancer Fibroblast growth factor receptor inhibitor Tyrosine kinase inhibitor Ligand trap Monoclonal antibody Gene amplification Genetic mutation Gene rearrangement
文章编号： 中图分类号：R735.2 文献标志码：A
基金项目:江苏省自然科学基金（BK20161110）；南京医科大学附属江宁医院青年创新科技基金一般项目（JNYYZXKY202123）；南京医科大学科技发展基金一般项目(NMUB2020160)；江苏卫生健康职业学院校级课题面上项目（JKC2021076）
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