Abstract:Objective To investigate the correlation between triglyceride-glucose (TyG) index and brachial-ankle pulse wave velocity (baPWV) in patients with obstructive sleep apnea (OSA). Methods From October 2020 to February 2023, 205 patients who underwent sleep-breathing monitoring at the Jiangbei Campus and the Cardiac Rehabilitation Center of Zhongda Hospital were selected. According to the quartile of TyG index, the patients were divided into Q1, Q2, Q3 and Q4 groups, and according to the sleep apnea hypopnea index (AHI), the patients were divided into no OSA plus mild OSA group and moderate plus severe OSA group. The relationships between baPWV and each index were evaluated. Results Among the 250 OSA patients, the higher the TyG index, the higher the proportion of male and hypertension, the higher levels of the body mass index (BMI), total cholesterol, triacylgycerol, low-density lipoprotein cholesterol, fasting blood glucose, uric acid, AHI and baPWV (P＜0.05), while the lower values of the age and mean blood oxygen saturation (P＜0.05). Compared with no OSA plus mild OSA group,the age, the proportions of male and hypertension, and levels of BMI, uric acid, AHI, and baPWV increased, while the lowest and average blood oxygen saturation deseased in moderate plus severe OSA group (P＜0.05). Pearson correlation analysis showed a positive correlation between the TyG index and AHI levels (r=0.217, P=0.002). Multiple linear regression analysis showed that age (β′=0.244， P＜0.01), uric acid (β′=0.140， P=0.013), hypertension (β′=0.128， P=0.016), AHI (β′=0.342， P＜0.01) and TyG index (β′=0.300， P＜0.01) were the influencing factors for baPWV，and AHI had the greatest influence, followed by TyG index. Conclusion The TyG index is related to the severity of OSA,and TyG index and the severity of OSA affect the level of baPWV. The use of the TyG index may help identify OSA patients and those at high risk of arteriosclerosis.