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Received:May 05, 2023 Published Online:December 20, 2023
Received:May 05, 2023 Published Online:December 20, 2023
中文摘要: 2型糖尿病（T2DM）患者比正常人更容易发生脑小血管病 (CSVD)，且对认知功能的损害有明确的关联。多元醇途径亢进、血管神经单元（NVU)的破坏、胰岛素抵抗和过度的氧化应激反应等是可能是其发病机制。本文对T2DM致CSVD发生发展的可能机制、T2DM伴CSVD的影像学特征及两者相关并发症的影响等进行综述，以促进对CSVD发病机制的探索及为特定的治疗提供线索。
Abstract:Patients with type 2 diabetes mellitus (T2DM) are more prone to cerebral small vessel disease (CSVD) than normal people, and there is a clear correlation between CSVD and cognitive impairment. The pathogenesis may be due to the hyperfunction of polyol pathway, the destruction of vascular nerve unit (NVU), insulin resistance and excessive oxidative stress reaction. This article reviews the possible mechanism of CSVD caused by T2DM, the imaging characteristics of T2DM with CSVD and the impact of their related complications, so as to promote the exploration of the pathogenesis of CSVD and provide clues for specific treatment.
keywords: Cerebral small vessel disease Type 2 diabetes mellitus Imaging features Hyperactivity of polyol pathway Vascular nerve unit Insulin resistance Oxidative stress response
文章编号： 中图分类号：R587.2 R743 文献标志码：A
基金项目:济宁市重点研发计划项目(2022YXNS051)
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