Abstract:Objective To explore the effect of pressure-controlled ventilation-volume guaranteed (PCV-VG) on lung ventilation in elderly patients with pancreatic cancer during operation. Methods A total of 68 elderly patients who underwent elective pancreaticoduodenectomy at The First Affiliated Hospital of Nanjing Medical University from June 2022 to April 2023 were selected as the study subjects. Among them, the V group consisted of 34 patients who received volume-controlled ventilation (VCV) during surgery. The P group consisted of 34 patients who received PCV-VG during surgery. Heart rate (HR) and mean arterial pressure (MAP) of patients were monitored and recorded at five time points: admission (T0), 5 minutes after tracheal intubation (T1), 30 minutes after surgery (T2), 90 minutes after surgery (T3), and end of surgery (T4). The peak airway pressure (P_peak), mean airway pressure (P_mean), dynamic lung compliance (Cdyn), and tidal volume (VT) of T1-T4 were recorded. T0-T4 arterial blood was collected for blood gas analysis, and PaO₂ and PaCO₂ were recorded. Results The P_peak of the P group was lower than that of the V group at all time points (P＜0.05), and the Cdyn was higher than that of the V group (P＜0.05). There was no significant difference in PaO₂, PaCO₂, HR and MAP between the two groups at each time point (P＞0.05). Conclusion Compared with VCV mode, PCV-VG mode can effectively reduce airway pressure, improve lung compliance, promote gas exchange, and have less impact on respiratory function in elderly patients undergoing pancreaticoduodenectomy.