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Received:March 13, 2023 Published Online:December 20, 2023
Received:March 13, 2023 Published Online:December 20, 2023
中文摘要: 目的 探讨心电图PR间期延长与糖尿病微血管并发症患者的一般资料及生化指标的相关性，及其对糖尿病微血管并发症的预测价值。
方法回顾性纳入2020年8月至2022年11月西安市第三医院内分泌科住院治疗的217例糖尿病患者为研究对象，其中149例单纯糖尿病患者为对照组，68例糖尿病微血管并发症患者为观察组。收集所有糖尿病患者一般资料及生化指标，采用标准12导联同步心电图机测量PR间期；分析糖尿病微血管并发症患者PR间期与一般资料及生化指标的相关性；采用受试者工作特征（ROC）曲线分析PR间期对糖尿病微血管并发症的预测价值。
结果 观察组年龄、糖尿病病程、身体质量指数（BMI）、糖化血红蛋白（HbA1c）、PR间期高于对照组（P＜0.01）。糖尿病微血管并发症患者PR间期与年龄、糖尿病病程、BMI、HbA1c均呈正相关（P＜0.01）。PR间期预测糖尿病微血管并发症的AUC为0.812（95%CI: 0.752~0.872），敏感度为70.6%，特异度为78.5%，最佳截断值为212.61 ms。PR间期延长是糖尿病微血管并发症的独立危险因素（OR＝2.745，95%CI: 1.472~5.120,P＜0.01）。
结论 糖尿病微血管并发症患者心电图PR间期明显延长，是影响糖尿病微血管并发症的独立危险因素，有助于预测糖尿病微血管并发症的发生。
Abstract:Objective To explore the correlation between the prolongating PR interval of electrocardiogram and the general information and biochemical indicators of diabetes patients with microvascular complications, and the predictive value of diabetes microvascular complications.
Methods A total of 217 patients with diabetes who hospitalized in Department of Endocrinology, Xi'an Third Hospital from August 2020 to November 2022 were selected retrospectively. Among them, 149 patients only with diabetes were divided into control group, while 68 diabetes patients with microvascular complications were divided into observation group. The general data and biochemical indexes of all diabetes patients were collected, and the PR interval was measured by standard 12 lead synchronous electrocardiograph. The correlation between PR interval and general data and biochemical indicators in patients with microvascular complications of diabetes were analyzed. The predictive value of PR interval on microvascular complications in diabetes was analyzed by receiver operating characteristic (ROC) curve.
Results Age, duration of diabetes, body mass index (BMI), hemoglobin A1c (HbA1c), PR interval in the observation group were higher than those in the control group (P＜0.01). PR interval of diabetes patients with microvascular complications was positively correlated with age, diabetes duration, BMI, HbA1c (P＜0.01). The AUC of PR interval for predicting microvascular complications in diabetes was 0.812 (95%CI:0.752-0.872), the sensitivity was 70.6%, the specificity was 78.5%, and the cut-off value was 212.61 ms. Prolonged PR interval was an independent risk factor for microvascular complications in diabetes (OR=2.475, 95%CI: 1.472-5.120, P＜0.01).
Conclusion In patients with microvascular complications of diabetes, the PR interval in electrocardiogrom is significantly prolonged. Prolonged PR interval is an independent risk factor for microvascular complications in diabetes, which is helpful to predict the occurance of diatetic microvascular complications.
keywords: Diabetes Microvascular complication Electrocardiogram PR interval Body mass index Hemoglobin A1c Diabetic nephropathy
文章编号： 中图分类号：R587.2 文献标志码：A
基金项目:陕西省重点研发计划项目（S2021-YF-YBSF-0079）
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