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Received:March 12, 2023 Published Online:November 20, 2023
Received:March 12, 2023 Published Online:November 20, 2023
中文摘要: 目的 探讨有宫内感染高危因素的先兆流产患者应用抗菌药物的效果及介入时机对妊娠结局的影响。方法 回顾性调查郑州市妇幼保健院2018年1月至2022年12月有宫内感染高危因素的先兆流产患者1 527例,按是否应用抗菌药物分为用抗菌药物组(n=471)和未用抗菌药物组(n=1 056),分别观察其妊娠结局;并观察两组存在1、2、≥3个宫内感染高危因素时对妊娠结局的影响。结果 两组孕产妇的年龄、孕次、体质量指数(BMI)、孕周延长值、产褥感染率及新生儿的胎龄、出生体重差异无统计学意义(P>0.05)。用抗菌药物组新生儿存活率低于未用抗菌药物组(61.36% vs 82.39%, χ2=78.735, P<0.01),存活新生儿中并发症发生率高于未用抗菌药物组(26.64% vs 10.57%, χ2=44.973, P<0.01)。分层分析显示,有1、2、≥3个宫内感染高危因素时,两组新生儿存活率和并发症发生率比较差异无统计学意义(P>0.05)。结论 用与不用抗菌药物对新生儿结局总体有影响,但在合并不同数量宫内感染高危因素分层中无差异。
Abstract:Objective To investigate the effect of applying antimicrobial drugs and the timing of intervention on pregnancy outcome in patients with risk factors for threatened abortion combined with intrauterine infection. Methods A retrospective survey of 1527 patients with risk factors for threatened abortion combined with intrauterine infection from January 2018 to December 2022 in Zhengzhou Women & Infants Hospital was conducted, divided into the group with antimicrobial drugs (n=471) and the group without antimicrobial drugs (n=1 056) according to whether antimicrobial drugs were applied, and their pregnancy outcomes were observed separately. The impact of the presence of 1, 2,≥3 intrauterine infection high-risk factors on pregnancy outcomes in both groups was also observed. Results There was no statistically significant difference in the age, parity, body mass index (BMI), gestational age prolongation, postpartum infection rate of pregnant women, fetal gestational age, and birth weight between the two groups (P>0.05). The neonatal survival rate in the antimicrobial agent group was lower than that in the non-antimicrobial agent group (61.36% vs 82.39%, χ2=78.735, P<0.01), and the rate of complications in surviving newborns was higher in the antimicrobial agent group compared to the non-antimicrobial agent group (26.64% vs 10.57%, χ2=44.973, P<0.01). Stratified analysis showed no statistically significant differences in neonatal survival rates and complication rates when there were 1, 2, ≥3 intrauterine infection high-risk factors in both groups (P>0.05). Conclusion There is an overall effect of using or not using antimicrobial drugs on neonatal outcome, but there is no difference in the stratification of different numbers of risk factors.
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基金项目:河南省医学科技攻关计划联合共建项目(LHGJ20200740)
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