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Received:February 10, 2023 Published Online:November 20, 2023
Received:February 10, 2023 Published Online:November 20, 2023
中文摘要: 目的 评估纳米炭示踪剂在甲状腺微小乳头状癌(PTMC)外科手术中的应用及其价值。方法 回顾性分析2017年1月至2022年12月在南京江北医院行手术治疗的165例PTMC患者的临床病理资料。依据术中是否采用纳米炭混悬液将患者分为纳米炭组(n=87)和常规组(n=78)。对比两组手术资料(手术时间、出血量、引流量等)、病理资料(淋巴结个数及阳性个数)、血清学指标(甲状旁腺激素和血钙)。结果 两组患者在引流量、住院日、出血量及手术时间方面差异无统计学意义(P>0.05)。纳米炭组清扫淋巴结的个数[(7.9±2.1)个vs(5.4±1.3)个,t=9.069,P<0.01]、阳性淋巴结的个数[(2.1±1.1)个vs(1.4±1.0)个,t=4.259,P<0.01]均多于常规组,且术后1 d和术后1个月的甲状旁腺激素和血钙水平均高于常规组(P<0.05)。术后1个月门诊复查时发现两组患者的血清甲状腺球蛋白值均较低,但差异无统计学意义(P>0.05)。结论 纳米炭示踪剂能够提高PTMC外科手术的临床获益,且安全有效。
Abstract:Objective To evaluate the application and value of nanocarbon tracer in the surgical treatment of papillary thyroid microcarcinoma (PTMC). Methods Retrospective analysis of clinical and pathological data of 165 PTMC patients who underwent thyroid cancer surgery at Nanjing Jiangbei Hospital from January 2017 to December 2022 was conducted. Patients were divided into the nanocarbon group (n=87) and the conventional group (n=78) based on whether carbon nanoparticles suspension was used during the surgery. Surgical data (such as operation time, blood loss, drainage volume), pathological data (number of lymph nodes and the number of positive nodes), and serological indicators (parathyroid hormone and blood calcium) were compared between the two groups. Results There was no statistically significant difference between the two groups in terms of drainage volume, length of hospital stay, blood loss, and operation time (P>0.05). The nanocarbon group had a higher number of cleared lymph nodes (7.9±2.1 vs 5.4±1.3,t=9.069,P<0.01) and positive lymph nodes (2.1±1.1 vs 1.4±1.0,t=4.259,P<0.01) than the conventional group, and the levels of parathyroid hormone and blood calcium at 1 day and 1 month after surgery were higher in the nanocarbon group compared to the conventional group (P<0.05). During the outpatient follow-up at 1 month after surgery, both groups had lower serum thyroglobulin values, but the difference was not statistically significant (P>0.05). Conclusion Nanocarbon tracer can improve the clinical benefits of PTMC surgery and is safe and effective.
keywords: Papillary thyroid microcarcinoma Nanocarbon tracer Lymph node dissection Parathyroid hormone Thyroglobulin
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