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Received:February 03, 2023 Published Online:October 20, 2023
Received:February 03, 2023 Published Online:October 20, 2023
中文摘要: 目的 探讨膝关节单髁置换术后发生下肢深静脉血栓(DVT)住院患者的临床特征以及DVT相关影响因素。
方法 回顾性分析2018年2月至2022年2月北京积水潭医院接诊并接受膝关节单髁置换术治疗的500例患者的临床资料,依据随访14 d后是否发生下肢DVT分为DVT组(n=225)和非DVT组(n=275)。收集并对比两组患者的实验室检查、病例资料,对膝关节单髁置换术后发生DVT的影响因素进行单因素分析。
结果 年龄≥60岁、BMI≥30 kg/m2、女性、术后未使用机械抗凝、凝血功能异常和高水平的D-二聚体(DD)、血管性血友病因子(vWF)、血清淀粉样蛋白A4(SAA4)、抗磷脂抗体(aPL)是膝关节单髁置换术住院患者发生DVT的影响因素(P<0.05)。
结论 膝关节单髁置换术住院患者年龄、BMI、性别、术后机械抗凝使用情况、凝血功能以及DD、vWF、SAA4、aPL等因素均会影响DVT的发生,应重点关注。
Abstract:Objective To explore the clinical characteristics of patients with lower limb deep venous thrombosis(DVT) after unicondylar knee replacement(UKR) and the related influencing factors of DVT.
Methods Retrospective analysis was made on the clinical data of 500 patients who were received UKR in Beijing Jishuitan Hospital from February 2018 to February 2022. According to whether DVT occurred in the lower limbs after 14 days of follow-up, the patients were divided into DVT group (n=225) and non DVT group (n=275). The laboratory examinations and clinical data of patients were collected and compared between two groups, and the influencing factors of DVT after UKR were analyzed by univariate analysis.
Results Age≥60 years, BMI≥30 kg/m2, female, no use of mechanical anticoagulation after operation, abnormal coagulation function, high levels of D-dimer (DD), von Willebrand factor (vWF), serum amyloid A4 (SAA4) and antiphospholipid antibody (aPL) were the influencing factors for DVT in patients received UKR (P<0.05).
Conclusion Age, BMI, gender, postoperative use of mechanical anticoagulation, coagulation function, DD, vWF, SAA4 and aPL can affect the occurrence of DVT in patients received UKR, which should be given special attention to.
keywords: Unicondylar knee replacement Lower limb deep venous thrombosis Coagulation function D-dimer von Willebrand factor Serum amyloid A4 Antiphospholipid antibody Mechanical anticoagulation
文章编号: 中图分类号:R687.4 文献标志码:B
基金项目:北京市卫生科技发展专项基金(2018-01-136)
Author Name | Affiliation |
JIA Xiaoxue, LI Chunmin | Orthopaedic Department, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing 102208, China |
Author Name | Affiliation |
JIA Xiaoxue, LI Chunmin | Orthopaedic Department, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing 102208, China |
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