Abstract:Objective To explore the clinical characteristics of patients with lower limb deep venous thrombosis（DVT） after unicondylar knee replacement（UKR） and the related influencing factors of DVT. Methods Retrospective analysis was made on the clinical data of 500 patients who were received UKR in Beijing Jishuitan Hospital from February 2018 to February 2022. According to whether DVT occurred in the lower limbs after 14 days of follow-up, the patients were divided into DVT group (n=225) and non DVT group (n=275). The laboratory examinations and clinical data of patients were collected and compared between two groups, and the influencing factors of DVT after UKR were analyzed by univariate analysis. Results Age≥60 years, BMI≥30 kg/m², female, no use of mechanical anticoagulation after operation, abnormal coagulation function, high levels of D-dimer (DD), von Willebrand factor (vWF), serum amyloid A4 (SAA4) and antiphospholipid antibody (aPL) were the influencing factors for DVT in patients received UKR (P＜0.05). Conclusion Age, BMI, gender, postoperative use of mechanical anticoagulation, coagulation function, DD, vWF, SAA4 and aPL can affect the occurrence of DVT in patients received UKR, which should be given special attention to.