本文已被:浏览 334次 下载 271次
Received:January 18, 2023 Published Online:October 20, 2023
Received:January 18, 2023 Published Online:October 20, 2023
中文摘要: 目的 探讨2型糖尿病(T2DM)患者血清尿酸/肌酐比值(SUA/SCr)对代谢综合征(MS)及其组分的早期筛查价值。
方法 对南京江北医院2020年10月至2022年7月收住的586例T2DM患者的临床资料进行回顾性研究。根据SUA/SCr水平的四分位值分为四组:<3.54为Q1组(147例),3.54~<4.35为Q2组(146例),4.35~<5.49为Q3组(147例),≥5.49为Q4组(146例)。分析SUA/SCr与MS及其组分(超重和/或肥胖、高血压、血脂紊乱)的相关性。
结果 随SUA/SCr的增高,患者年龄、T2DM病程、HDL-C、SCr水平降低,男性比例、BMI、DBP、TC、TG、SUA水平以及MS及其组分超重和/或肥胖、血脂紊乱患病率增高(P<0.05)。Pearson相关性分析显示,校正年龄、性别、病程、吸烟、饮酒后,SUA/SCr与BMI、DBP、TG呈正相关,与HDL-C、HbA1c呈负相关(P<0.05)。Logistic回归分析显示,校正年龄、性别、病程、吸烟、饮酒后,以Q1组为参照,Q2组、Q3组、Q4组MS患病风险分别显著增加了85%(OR=1.85)、70%(OR=1.70)、313%(OR=4.13),差异有统计学意义(P<0.01);超重和/或肥胖、高血压、血脂紊乱患病风险也显著增加。SUA/SCr与MS患病风险呈剂量—反应关系,SUA/SCr每升高1个单位,MS患病风险显著增加31%(OR=1.31,P<0.05)。
结论 T2DM患者SUA/SCr升高与MS及其组分患病风险增加密切相关,SUA/SCr可作为MS的早期生物标志物,为防治及逆转MS提供新的科学依据。
Abstract:ObjectiveTo explore the correlation between serum uric acid-to-creatinine ratio(SUA/SCr) and metabolic syndrome(MS) and its components in patients with type 2 diabetes mellitus(T2DM).
Methods A retrospective study was conducted on 586 patients with T2DM admitted to Nanjing Jiangbei Hospital from October 2020 to July 2022, According to the quartile of SUA/SCr levels, they were divided into four groups: Q1 group (n=147) with<3.54, Q2 group (n=146) with 3.54 to <4.35, Q3 group (n=147) with 4.35 to <5.49 and Q4 group (n=146) with ≥ 5.49. The correlations bewteen SUA/SCr and MS and its components (overweight and/or obesity, hypertension, dyslipidemia) were analyzed.
Results As SUA/SCr increased, patients age, T2DM course, HDL-C and SCr levels decreased, while male proportion and BMI, DBP, TC, TG, SUA levels, as well as the prevalence of MS and its components (overweight and/or obesity, dyslipidemia) increased (P<0.05). Pearson correlation analysis showed that SUA/SCr was positively correlated with BMI, DBP and TG ,and negatively correlated with HDL-C and HbA1c (P<0.05) after adjusting for age, sex, duration of disease, smoking and drinking. Logistic regression analysis showed that after adjusting for age, sex, duration of disease, smoking and drinking, compared with Q1 group, the risk of MS in Q2 group, Q3 group and Q4 group increased significantly by 85% (OR=1.85), 70% (OR=1.70) and 313%(OR=4.13), respectively,with statistical significances (P<0.01).The risk of overweight and/or obesity, hypertension and dyslipidemia also significantly increased.There was a dose-response relationship between SUA/SCr and the risk of MS, and the risk of MS increased by 31% when SUA/SCr increased by one unit (OR=1.31, P<0.05).
Conclusion The increase of SUA/SCr level in T2DM patients is closely related to the increased risk of MS and its components. SUA/SCr can be used as an early biomarker of MS, which provides a new scientific basis for the prevention, treatment and reversal of MS.
keywords: Type 2 diabetes mellitus Serum uric acid-to-creatinine ratio Metabolic syndrome Overweight and/or obesity Hypertension Dyslipidemia
文章编号: 中图分类号:R58 文献标志码:B
基金项目:
Author Name | Affiliation |
XU Ting, WANG Cui, REN Jian, ZAI Guotian | Department of Endocrinology, Nanjing Jiangbei Hospital Afficated to Nantong University Xinglin College, Nanjing, Jiangsu 210048, China |
Author Name | Affiliation |
XU Ting, WANG Cui, REN Jian, ZAI Guotian | Department of Endocrinology, Nanjing Jiangbei Hospital Afficated to Nantong University Xinglin College, Nanjing, Jiangsu 210048, China |
引用文本: