Abstract:Sepsis is mostly accompanied by functional damage to the intestinal mucosal barrier, in which mechanical mucosa of the intestinal epithelium is the basic structure of the intestinal mucosal barrier, and its molecular mechanism of injury is particularly important. In the molecular mechanism of injury, the waterfall inflammatory mediator and related cytokines mediated by sepsis are the main injuring factors. This paper summarizes the relevant factors and molecular mechanisms of sepsis-related intestinal epithelial mechanical barrier injury, in order to provide a new idea for the treatment of sepsis.