Abstract:Objective To explore the effect of magnetic resonance imaging （MRI） and contrast enhanced ultrasound （CEUS） in the grading diagnosis of glioma. MethodsA retrospective analysis was performed on the patients without glioma （control group, n=94） and with glioma （observation group, n=96） treated in No. 215 Hospital of Shaanxi Nuclear Industry from April 2017 to April 2022. All patients received CEUS and MRI examinations before surgery. Time to peak （TTP）, mean transit time （mTT）, pure water diffusion coefficient （D）, perfusion fraction （f） and quantitative indicators were compared between two groups. During six months after operation, 29 cases of residual tumor were found by histopathology examination. ResultsIn observation group, TTP, D, f were statistically higher than those in control group, mTT was lower than that in control group （P ＜ 0.05）. Compared with those in the patients with low-grade tumor, TTP, D and f increased significantly, and mTT decreased in the patients with high-grade tumor （P ＜ 0.05）. ROC curve analysis showed that the AUCs of TTP, mTT, D, f and joint prediction for glioma grading were 0.849, 0.839, 0.914, 0.893 and 0.971, respectively. ConclusionCEUS combined with MRI has a higher efficiency in predicting the grade of glioma and postoperative residual tumors, which can provide a scientific basis for prognosis evaluation.