Abstract:ObjectiveTo analyze the clinical efficacy and prognostic influencing factors of neuro-endoscopic minimally invasive surgery for hypertensive intracerebral hemorrhage （HICH）. MethodsA total of 100 patients with HICH admitted to Handan First Hospital from January 2020 to December 2021 were randomly divided into control group （n=50） and observation group （n=50）. The control group underwent small bone window craniotomy for hematoma debridement, and the observation group underwent neuro-endoscopic minimally invasive surgery. The hematoma clearance, National Institutes of Health Stroke Scale （NIHSS）, Activity of Daily Living (ADL) and prognosis were compared between two groups. According to the prognosis, patients in observation group were divided into good prognosis sub-group （n=37） and poor prognosis sub-group （n=13）, and the influencing factors were analyzed. ResultsThe intraoperative blood loss and postoperative residual hematoma in observation group were less than those in control group, and the hematoma clearance rate was higher than that in control group （P＜0.05）. One month after operation, the good prognosis rate of observation group was higher than that of control group （74.00%vs48.00%, χ2=7.104, P＜0.05）. The preoperative MAP ［(122.57±7.88) mmHgvs(130.26±8.97) mmHg, t=2.921, P<0.05］, hematoma volume ［(39.51±3.65) mLvs(45.06±3.14) mL, t=4.877, P<0.05］, NIHSS score ［(15.63±1.23) vs (18.64±1.25), t=2.921, P<0.05］ of the good prognosis subgroup were all lower than those of the poor prognosis subgroup, and preoperative GCS score was higher than that of the poor prognosis subgroup ［(10.84±2.39)vs(8.41±2.26), t=3.196, P<0.05］. ConclusionNeuro-endoscopic minimally invasive surgery for HICH patients can help to clear hematoma, restore nerve function and improve prognosis. And preoperative MAP, hematoma volume, GCS, and NIHSS are associated with prognosis.